Cause of Obesity- Maladaptation or addiction
What is the cause of obesity epidemic? For all life on Earth, food is not a choice. The hardest thing for the animal in the wilderness is to gain weight.
Milos Pokimica
Written By: Milos Pokimica
Medically Reviewed by: Dr. Xiùying Wáng, M.D.
Updated June 9, 2023What is the cause of obesity epidemic? Can the obesity epidemic be reversed if we understand the cause of obesity?
Obesity is a complex disease and it is a disease characterized by an excess of body fat. Obesity is more than just a cosmetic issue. It is a medical condition that raises the risk of developing other diseases and health issues, such as heart disease, diabetes, high blood pressure, and certain cancers.
Some people struggle to lose weight for a variety of reasons but the main one is that our brain acts in an evolutionary protective manner. In other words, the cause of obesity is maladaptation to our current environment. Scarcity is the rule in nature and an overabundance of food never existed in our 50 million-long history.
When you go to the obesity clinic and ask what is the cause of obesity, and what you have to change in your life, you won’t receive a decisive answer. The reason is that conventional allopathic medicine works as a reductionist practice. The cause of obesity is maladaptation which is a decisive answer. But this answer requires a holistic approach and a reductionist approach is what you get in hospitals. Holistic medicine does not have a patent or operation pending so there is no profit to pay for someone’s engagements. That is a reason why they don’t tell you the whole truth about the cause of obesity epidemic. Prescription medications and weight-loss procedures are additional options for treating obesity that make a lot of money besides supplements and other programs but all of them remember of they do not treat the root cause of the obesity epidemic. You can lose weight bat the condition that made you gain weight is still there as an evolutionary protective mechanism and it is very little we can do about it.

The cause of obesity is embedded into our genome and it is embedded into the genome of every species on this planet. All of the species on Earth are going to become obese if there is an abundance of food not just our pets. Animals as well as humans eat as much as they can every time they can. We can start to explain the cause of obesity in a scientific manner. We can start to look into genomes a do a line of studies, we can start to experiment with different hormones, and different food types, then we can do a line of studies involving neurochemicals and brain signaling. In this way, maybe studies will be able to give us some magic injection or pill to deal with this condition but the cause of obesity remains a complex mechanism rooted in maladaptation.
The majority of people think about weight loss because of the sex appeal. Health considerations are not always the primary reason for dieting. However, in cases of morbid obesity when the doctor tells patients to lose weight or die, health considerations come into play patients will try to lose weight. Most of the entire population will in their lifetimes at some point be on a diet for one reason or the other. In most cases, dieting would not give any long-term and lasting results.
But why? What is the cause of obesity? Let’s look into it in more detail.
An evolutionary adaptation is any heritable phenotypic character whose frequency of appearance in a population is the result of increased reproductive success. Adaptation is the development that the organism goes through in order to become accustomed to an environment. It is linked to evolution because it is a long process. One that occurs over many generations. Genetic change is what occurs.
Habitats do often change. Consequently, the process of adaptation is never finally complete. With time, it may result that the habitat changes to some extent and that species adapt to fit its surroundings better and better.
It may also happen that the environment changes very little and that species do not need to adapt at all. Examples of this can be seen in so-called living fossils like jellyfish that evolved 550 million years ago. Also, variations in the habitat may happen almost immediately, resulting in species growing less and less well-adapted and eventually going extinct.
What does evolutionary adaptation have to do with our diet and why is this important?
We have to understand how abrupt shifts in our environment caused by technological progress and our modern way of living can affect our biology that is not adapted to it and how it might affect our health. Another solution would be to act impulsively, emotionally, and instinctively like most other animals. That is precisely what we can see when we visit hospitals and give most of our income on the good service of modern medicine.
Animals eat impulsively because they are conditioned to do it for survival. For all life on the planet Earth, food is not a choice. The hardest thing for an animal in the wilderness is to gain weight. The hardest thing for us is to lose it.
And this is only because of technological progress in the last couple of centuries. That progress has enabled our current generation to eat as much as we want and whenever we want. We have a shift in our understanding of food and we have started to treat food as a source of gratification. The problem is that If we do start to treat food as a source of gratification and make dietary choices that are based on feelings and satisfaction, like it or not it will have health consequences.
For most of our evolution, we were slim in a state of constant hunger and constant physical activity, naked, and eating mostly vegan food.
The only reasonable assumption is that hominins eat like any other animal. This means only in situations when they did find food. This was the case for all of our ancestor species and that means the time period of 50 million years. Hunger like exercise is something that our physiology is adapted to and expects it. We will not die if we don’t eat. Homo erectus did not have a fridge to go to in the middle of the night when he felt like eating. Hunger is a normal feeling for every animal. This includes humans as well. The feeling is so strong that has the ability to condition our behavior and override any other instinct. It has to be so that it would be able to force the animal to search for it or it will die. On the other side, a feeling of constant fullness is not natural.
Even when we are on a restrictive diet modern people will like to have a feeling of fullness. So here comes caffeine, hunger suppressors of different kinds, and so on. If we can just find a magical, all-you-can-eat, weight-loss diet. Evolutional conditioning is so strong that in many cases after dieting people can develop a fear of starvation and will be in a constant struggle not to overeat even if they are not hungry. We are surrounded by food everywhere and plus on top of that, we can eat sugar and fat in an isolated refined form that we were never able to find in nature giving ourselves something known as supernormal stimuli or in other words, food dopamine high.
On one side, there is starvation and on another unnatural release of dopamine triggered by unnatural food that we have never been exposed to in our evolution. This is what causes a binge eating disorder and obesity, 50 million years of scarcity, and starvation.
Where is the malfunction? The cause of obesity dilemma and epidemic remained shrouded in complexity and mystery. There was a range of clinical trials that have somewhat confirmed this and this is my personal opinion also that obesity conditions are `maladaptations’ of actual current modern lifestyle to our genome (Fernandez-Real & Ricart 1999). In other words, maladaptation is something that occurs in an abrupt shift of habitat that physiology is not adapted to cope with.
In the case of obesity, the standard regulatory system will tell the brain that we have fat deposits stored for an extended period and that we can endure little hunger. However, hominins could never become fat due to scarcity, so they never developed an adaptation to the abundance of food. Our mind still thinks that if we do not eat all that we can we will starve to death in the upcoming drought.
Even our concept of beauty changed. I do not mean what we were thinking is pretty in ancient Egypt or Persia. That is a form of modern agricultural civilization with societal structures. Before civilization and agriculture in the Paleo period and beyond, hunter-gathers idealized morbid obesity. We can see a physical example of this in morbid obesity Venus figurines that were found in different locations from the Paleo period.

Because there was never an abundance of food and for their entire life during the Paleo period and before and for our entire evolution there was scarcity, the concept of morbid obesity was nothing more than idolized fiction. A fairytale of life without starvation. We have to understand the difference between foraging and hunter-gathering and agriculture, and then agricultural societies and our modern industrial ones are significant. They are enormous regarding evolutional biology. It was all about survival.
The skinny, malnourished female was in danger if became pregnant. Living in nature might seem romantic today but for our ancestors, it was a constant nightmare with an average lifespan of 25 years. In Ice Age in Europe during winter (the last glacial period from 110,000 – 11,700 years ago), a malnourished pregnant woman would have many problems. Morbid obesity is a symbol of fertility or a symbol of successful pregnancy and a symbol of life itself. Our paleo grandparents did not understand the full range of functioning of biological principles, but they for sure understand the role of adipose tissue for survival. It was the way of life ever since our ancestors moved out of Africa and entered colder climates, and even in Africa actually, there was no overabundance of sources of food around also. In snow and ice and caves with constant hunger and other hominins around competing for food, it was the worst-case scenario. That is why we can see morbid obesity Venuses figurines.
After the Neolithic Revolution, it all shifted rapidly. There were the first larger cities and societal hierarchies. Also, the concept of fertility shifted everywhere. Goddesses became slimmer, stories grew into religion, and morphed into the culture.
Eating healthy still does not mean that we will override our hunger drive. There is no magic cure for survival signaling except for strong medications. Eating healthy can still make us obese. The healthy diet is just the one we had evolved and adapted to eating. That is it. It is not a restrictive diet.

It is not the tastiest diet also. In nature, there is scarcity, so taste exists as a reward, not as a common theme for every meal.
For every animal in existence in nature, hunger is the normal state of being. Alternatively, a constant struggle for food would be more precise. For every animal that lives on this planet, food obsession is a daytime job. Most of the time during their lives animals spend searching for food. There are no supermarkets and cans of ready-to-eat meals. It is a struggle. Moreover, that was a normal condition for humans even today. Well, at least the body physiology part.
Our desire and pleasure-seeking behavior are what make us sick. Evolution did not predict electricity and microchips and cars. We are maladapted to our habitat. We have underlined mechanisms that force us to act in an evolutionary protective manner such as overeating food. The not-so-unique obstacle now is that there is no scarcity anymore.
References:
Passages selected from a book: Pokimica, Milos. Go Vegan? Review of Science Part 1. Kindle ed., Amazon, 2018.
- Anderberg, Rozita H et al. “The Stomach-Derived Hormone Ghrelin Increases Impulsive Behavior.” Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol. 41,5 (2016): 1199-209. doi:10.1038/npp.2015.297
- Al Massadi, Omar et al. “Ghrelin and food reward.” Neuropharmacology vol. 148 (2019): 131-138. doi:10.1016/j.neuropharm.2019.01.001
- Johnson, Paul M, and Paul J Kenny. “Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats.” Nature neuroscience vol. 13,5 (2010): 635-41. doi:10.1038/nn.2519
- Palmiter, Richard D. “Is dopamine a physiologically relevant mediator of feeding behavior?.” Trends in neurosciences vol. 30,8 (2007): 375-81. doi:10.1016/j.tins.2007.06.004
- Obradovic, Milan et al. “Leptin and Obesity: Role and Clinical Implication.” Frontiers in endocrinology vol. 12 585887. 18 May. 2021, doi:10.3389/fendo.2021.585887
- Crujeiras, Ana B et al. “Leptin resistance in obesity: An epigenetic landscape.” Life sciences vol. 140 (2015): 57-63. doi:10.1016/j.lfs.2015.05.003
- Peng, Jin et al. “Central and peripheral leptin resistance in obesity and improvements of exercise.” Hormones and behavior vol. 133 (2021): 105006. doi:10.1016/j.yhbeh.2021.105006
Related Posts
Do you have any questions about nutrition and health?
I would love to hear from you and answer them in my next post. I appreciate your input and opinion and I look forward to hearing from you soon. I also invite you to follow us on Facebook, Instagram, and Pinterest for more diet, nutrition, and health content. You can leave a comment there and connect with other health enthusiasts, share your tips and experiences, and get support and encouragement from our team and community.
I hope that this post was informative and enjoyable for you and that you are prepared to apply the insights you learned. If you found this post helpful, please share it with your friends and family who might also benefit from it. You never know who might need some guidance and support on their health journey.
– You Might Also Like –

Learn About Nutrition
Milos Pokimica is a doctor of natural medicine, clinical nutritionist, medical health and nutrition writer, and nutritional science advisor. Author of the book series Go Vegan? Review of Science, he also operates the natural health website GoVeganWay.com
Medical Disclaimer
GoVeganWay.com brings you reviews of the latest nutrition and health-related research. The information provided represents the personal opinion of the author and is not intended nor implied to be a substitute for professional medical advice, diagnosis, or treatment. The information provided is for informational purposes only and is not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider.NEVER DISREGARD PROFESSIONAL MEDICAL ADVICE OR DELAY SEEKING MEDICAL TREATMENT BECAUSE OF SOMETHING YOU HAVE READ ON OR ACCESSED THROUGH GoVeganWay.com
NEVER APPLY ANY LIFESTYLE CHANGES OR ANY CHANGES AT ALL AS A CONSEQUENCE OF SOMETHING YOU HAVE READ IN GoVeganWay.com BEFORE CONSULTING LICENCED MEDICAL PRACTITIONER.
In the event of a medical emergency, call a doctor or 911 immediately. GoVeganWay.com does not recommend or endorse any specific groups, organizations, tests, physicians, products, procedures, opinions, or other information that may be mentioned inside.
Editor Picks –
Milos Pokimica is a health and nutrition writer and nutritional science advisor. Author of the book series Go Vegan? Review of Science, he also operates the natural health website GoVeganWay.com
Latest Articles –
Top Health News — ScienceDaily
- Ozempic may have revealed the brain’s hidden “craving center”on August 12, 2026
Ozempic-like drugs appear to weaken more than hunger—they may also reduce cravings for alcohol and other addictive substances. Scientists are increasingly tracing this effect to the lateral septum, a brain region that helps connect memories and surroundings with rewarding experiences. Packed with GLP-1 receptors, it may act as a crucial control point between thinking about a reward and feeling compelled to pursue it. The discovery could open new approaches to treating addiction as well as […]
- Scientists discover a hidden brain rhythm that could improve Parkinson’s treatmenton August 12, 2026
Scientists have pinpointed a brain network—and its distinctive electrical rhythm—that appears to drive the benefits of deep brain stimulation for Parkinson’s disease. The discovery could lead to more precise, personalized stimulation settings and better results for patients.
- 3,500-year-old skeletons challenge what scientists thought they knew about syphilison August 12, 2026
Ancient remains from Vietnam suggest diseases like yaws may have been passed from mother to child thousands of years ago, a form of transmission often assumed to indicate syphilis. The discovery could overturn how scientists interpret ancient infections and complicate the long-running mystery of syphilis’s origins.
- The adult brain can repair itself better than scientists thoughton August 12, 2026
The adult brain may be far better at repairing itself than scientists once believed. In mice, researchers discovered a special group of support cells called astrocytes that respond to damaged brain tissue by rebuilding lost cellular networks. Rather than simply moving into the injured area, these cells perform a remarkable maneuver: they create new nuclei and send them traveling through long cellular extensions to repopulate damaged regions.
- Scientists turn sheep’s wool into a material that helps regrow boneon August 12, 2026
Keratin extracted from sheep’s wool helped damaged bone regenerate in animals, producing tissue that was more organized and structurally similar to healthy bone than tissue grown with conventional collagen scaffolds. The discovery could turn an abundant agricultural byproduct into a promising new material for regenerative medicine.
- MIT neuroscientists discover the brain can reason without wordson August 11, 2026
MIT neuroscientists have found striking evidence that language and logical reasoning are powered by separate systems in the brain. Even people with severe language impairments caused by stroke were able to solve challenging logic puzzles as well as people without those impairments, while brain scans showed that language-processing regions stayed largely quiet during reasoning tasks.
- Marine heatwaves are harming human health in surprising wayson August 11, 2026
Marine heatwaves are emerging as a threat not just to coral reefs and fisheries, but to human health and well-being. Researchers warn that unusually hot oceans can fuel stronger storms, trigger harmful algal blooms, reduce seafood supplies, disrupt livelihoods, and contribute to anxiety, grief, and depression in coastal communities.
PubMed, #vegan-diet –
- Dietary Quality Along a Plant-Based Continuum: The Role of Added Salt, Oil, and Sugar in Chronic Disease Riskon August 13, 2026
Chronic noncommunicable diseases, including cardiovascular disease (CVD), type 2 diabetes (T2D), and cancer, constitute leading causes of global mortality, with suboptimal diet identified as a primary modifiable risk factor. Plant-based dietary patterns (PBDPs) can be conceptualized along a continuum of quality, with whole-food PBDPs consistently linked to lower risks of CVD, T2D, and all-cause mortality, though much of this evidence derives from studies of vegan or healthy plant-based […]
- Dietary Acid Load Across Vegans, Lacto-Ovo-Vegetarians, Fish-Eaters, and Meat-Eaters, and Its Association with Body Mass Index: A Secondary Analysis from an Italian Survey (The INVITA Study)on August 13, 2026
Diet represents a key determinant of the body’s acid-base balance because foods are metabolized into non-volatile acids or bases. An increase in dietary acid load can elicit low-grade metabolic acidosis, which has been associated with systemic inflammation and the risk of adverse cardiometabolic conditions, including obesity. Potential renal acid load (PRAL) and Net Endogenous Acid Production (NEAP) represent the major markers of dietary acid load. The aim of this secondary analysis was to…
- Effect of Ketogenic Diet Versus Vegan Diet on Obesity-Induced Testicular Dysfunction and Mediating Role of Gut Microbiotaon August 13, 2026
Obesity is associated with metabolic dysregulation and impaired male reproductive capacity, where the gut microbiota affects male reproductive function through diverse mechanisms that warrant further elucidation. This study aims to evaluate the effects of ketogenic and vegan dietary interventions in attenuating obesity-associated testicular injury and to examine the extent to which specific gut microbiota profiles mediate their impact. Forty-nine male adult albino rats were assigned to seven…
- Nutrient and Discretionary Food Intake in Vegan Adult Australians: A Cross-Sectional Studyon August 12, 2026
Interest in plant-based diets, including vegan diets is increasing. Yet, there has been limited assessment of the dietary intake of contemporary vegans in Australia. Sixty-six adult Australian vegans completed a four-day, semi-weighed food diary on two occasions. Intake from diet and supplements and diet alone was compared to the Australian Nutrient Reference Values (NRVs) for selected nutrients. Risk of micronutrient inadequacy was assessed using the cut-point method, with comparison to the…
- Similar Muscle Recovery but Greater Soreness in Active Vegans on Low-Protein Diets Compared to High-Protein Omnivores Following Exercise-Induced Damageon August 12, 2026
To assess whether a low-protein vegan diet is associated with differences in recovery from exercise-induced muscle damage (EIMD) in physically active individuals. Physically active vegans (n = 7) and omnivores (n = 7) underwent a lower-body muscle damage protocol consisting of five sets of repetitions to failure using the Smith machine squat and leg press at 85% of one-repetition maximum (1RM). Muscle damage and recovery were assessed at baseline, immediately post-exercise, and at 24, 48, and […]
Random Posts –
Featured Posts –
Latest from PubMed, #plant-based diet –
- From Diet to Dysbiosis: How Nutritional Factors Shape Gut Microbiota and Drive Airway Inflammation in Pediatric Asthmaby Oana Raluca Temneanu on August 13, 2026
Asthma prevalence in school-age children varies widely by geography, from below 5% in some regions to above 20% in others, averaging 10-12% across industrialized countries, but genetic factors account for less than 40% of disease liability. Gut microbiota is increasingly recognized as a critical intermediary between early-life dietary exposure and immunological trajectories that determine asthma susceptibility. Through the production of short-chain fatty acids (SCFAs), particularly butyrate,…
- Rethinking Mediterranean Diet Adherence and Body Composition: A 3-Year Prospective Observational Study in Patients with Type 2 Diabetes and Arterial Hypertensionby Dora Bučan Nenadić on August 13, 2026
Background/Objectives: Type 2 diabetes mellitus (T2DM) and arterial hypertension (AH) frequently coexist and are major risk factors for cardiovascular disease (CVD) and chronic kidney disease. Although the Mediterranean diet (MeDi) is widely recommended in cardiometabolic management, longitudinal real-world evidence regarding dietary adherence, body composition, and the role of continuous dietitian-led follow-up remains limited. Methods: This three-year prospective observational study […]
- Nutrition and Hydration Strategies for Heatwave Adaptation: A Narrative Reviewby Stefania D’Angelo on August 13, 2026
Climate change is increasing the frequency, intensity, and duration of heatwaves, making extreme heat a recurrent public health challenge with important nutritional implications. High ambient temperatures affect human health through thermoregulatory strain, sweating, dehydration, electrolyte imbalance, cardiovascular and renal stress, impaired cognitive and physical performance, and exacerbation of chronic diseases. Diet and hydration may therefore represent modifiable, although still…
- Dietary Patterns, Eating Disorder Risk, Emotional Distress, and Amino Acid Intake in Adults Seeking Weight Lossby Alessia Placanica on August 13, 2026
Background: Diet quality and amino acid intake influence both physical health and psychological well-being, potentially affecting eating disorder risk. This study aimed to investigate the relationship between dietary patterns, amino acid intake, and eating disorder risk. Methods: This cross-sectional study included 130 adults with overweight or obesity. All participants were assessed for eating disorder risk and body image distortion. Dietary intake was assessed using a validated food […]
- Dietary Quality Along a Plant-Based Continuum: The Role of Added Salt, Oil, and Sugar in Chronic Disease Riskby David M Goldman on August 13, 2026
Chronic noncommunicable diseases, including cardiovascular disease (CVD), type 2 diabetes (T2D), and cancer, constitute leading causes of global mortality, with suboptimal diet identified as a primary modifiable risk factor. Plant-based dietary patterns (PBDPs) can be conceptualized along a continuum of quality, with whole-food PBDPs consistently linked to lower risks of CVD, T2D, and all-cause mortality, though much of this evidence derives from studies of vegan or healthy plant-based […]
- Impact of a Behavioral Lifestyle Intervention on Dietary Habits, Anthropometric and Psychological Outcomes, and Biomarkers of Oxidative Stress and Telomere Length in Adultsby Panagiota Galatoula on August 13, 2026
Background/Objectives: Lifestyle-related behaviors and chronic stress are key determinants of metabolic health, psychological well-being, and biological aging. Structured behavioral interventions that enhance self-awareness and self-regulation may promote sustained improvements across multiple health domains. This study aimed to evaluate the effects of a six-week Pythagorean Self-Awareness Intervention (PSAI) on dietary habits, anthropometric and psychological outcomes, and biomarkers of…
























