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by Milos Pokimica ND

by Milos Pokimica ND

Learn About Nutrition

Obesity Risk Factors

"What are the associated obesity risk factors? For all life on the planet Earth, except for us, food is not a choice."
morbid obesity
Morbid Obesity
morbid obesity
Morbid Obesity
morbid obesity
Morbid Obesity

What are the associated obesity risk factorsAnimals eat impulsively because they are conditioned to do it for survival. For all life on the planet Earth, food is not a choice. It is a daytime job of survival. The hardest thing for an animal in the wilderness is to gain weight. There is no overabundance in nature because as soon as there is, the number of animals will increase and the new balance will be achieved. This will again create a situation of constant hunger.

obesity evolution

However, in a modern technologically driven society, there is no scarcity. This is the reason why the hardest thing for us is to diet. For most of our evolution, we were slim in a state of constant hunger as any other animal. This was the case for all of our ancestor species and that means the time period of 50 million years. The obesity epidemic today is maladaptation that is caused by the overabundance of food. This is a new normal and the old normal of dying from starvation is the thing of the ancient past. The problem is that ”ancient” is not really ancient in evolutionary terms. Evolution works for millions of years. The obesity epidemic is therefore more than just a cosmetic issue. It is a health issue that we have to cope with and as a consequence, we will have risk factors that will be associated with it. Being overweight is not a cultural acceptance issue it is a health issue that will never be going to go away.

What are the associated obesity risk factors? The body fat percentage (BFP) measures the total fat that you have. Body mass index measures total mass depending on tallness and are different from Body fat percentage. If we have greater muscle mass or larger bones, we will have a higher BMI, so it tells us nothing about fat percentage.

skinny fat
Skinny to Skinny-Fat

For example, there is the so-called “skinny fat” body type, where you have high BMI and high BFP or in other words, you are obese and at the same time, you have low muscle mass. Or you can have a high BMI and low BFP like bodybuilders do. Body fat percentage in the leanest athletes is typically at levels of about 6–13% for men or 14–20% for women, this means full six-pack abs and a general shredded look.

body fat percentage
Body Fat Percentage

Also, there is something called visceral fat, and that is fat that we cannot see. The fat we may be capable of touching on our arms and legs is subcutaneous fat. This internal visceral fat encloses essential organs like the liver, heart, and kidneys and is called organ fat, intra-abdominal fat, or visceral fat. When you are overweight you have more fat inside than you might think. In essence, if we are obese we will have more fat inside than outside. A growing belly can be the result of both types of fat.

Carrying a large quantity of visceral fat is associated with stroke, heart disease, insulin resistance, osteoarthritis, gout, sleep apnea, asthma, breast cancer, and colorectal cancer. Individuals with a body mass index (BMI) of 30 or higher are considered obese. The term obesity is used to describe individuals who have a weight that can start to cause them health problems and is significantly above their ideal healthy weight. The term morbid obesity is used for individuals that have problems in their regular daily activities due to excessive weight gain. It is a form of disability. Nearly 70% of American adults are either overweight or obese.

bmi chart

Excess weight may increase the risk for many health problems, including:

  1. Type 2 diabetes
  2. High blood pressure
  3. Heart disease and strokes
  4. Certain types of cancer
  5. Sleep apnea
  6. Osteoarthritis
  7. Fatty liver disease
  8. Kidney disease
  9. Pregnancy problems (high blood sugar, high blood pressure)

When we talk about risk factors associated with obesity we mean only the diseases that exercise weight is going to create just by itself. In reality, the situation is very different because people that are obese usually at the same time have a very unhealthy diet. It is possible to gain a lot of weight on a nutritionally optimized whole food diet but in reality, extracted sugar and fat and other refined products make a big chunk of calories that creates the excessive caloric intake in the first place.

Having excessive weight in a more realistic condition also means having high cholesterol, high saturated fat, low mineral, low vitamin, low phytochemical and antioxidant, and high pro-inflammatory nutrient-deprived diet. Most of the people that read this will have a hard time understanding that we have in reality a situation where most of the obese people are also malnourished at the same time. In nutrition, there is a term “junk food” or “empty calorie”. It is similar to the “skinny fat” phenomenon.

Nutrition deficiency affects most of the population at the same time when most population is overweight. Nutritional deficiencies are a wide topic especially because the land that is used to produce food is depleted and that means that crops will be depleted and that means that animal fed will be depleted. On top of that food is refined and the end result is hypercaloric addictive food filled with calories and nothing much else. In situations where obese people want to go on a calorie-restricted diet and are already malnourished and deficient in most of the essential and non-essential nutrients, we could have a situation that will create a wide range of diseases and all of that diseases will not be directly correlated to obesity but in a sense they are. Eating organic food has much less to do with pesticide residues or with genetically modified organisms but much more to do with low quality eroded land where these food are grown. In organic farming using synthetic fertilizers is forbidden.

Heart disease and stroke

obesity and heart disease
Obesity and Heart Disease

Besides carrying large amounts of visceral fat hypercaloric diet also in practice means a higher load of nutrients that our body is also not adapted well at metabolizing. A good example of this is cholesterol. In herbivore species, because they do not eat meat the cholesterol is produced by the liver and they do not need to eat it for their entire life. But when we start to overeat then our body will not be able to metabolize it and that will create additional deposits on blood vessels that will create an increase in risk factors from cardiovascular disease. Obesity on top of that independently just by weight creates increasing pressure on the heart muscle. The increased pressure and all of the cholesterol deposits then create pressure in small or for that measure even larger blood vessels that can be clogged. This will then lower the blood flow and as a response body will increase pressure to increase flow or some of the organs can be left without blood supply. An increase in pressure and deposited fat on the lining and inflammation then can lead to cascading of bad effects. Stroke for example is the same disease as a heart attack with a different outcome. Obesity will create a higher risk from a stroke. There are actually two main types of stroke, ischemic stroke hemorrhagic stroke. In the first one, there will be a clogging of the artery and in another type, the artery will burst open. Both of them are associated with obesity.

Excess estrogen, low testosterone, low growth hormone

obesity estrogen cycle

Adipose tissue is not a dead organ that sits there and does nothing. It is actually an active organ that has enzymes and is metabolically active. For example, fat cells have enzymes that will metabolize testosterone into estrogen. The enzyme is called aromatase. In breast cancer or in bodybuilding for example one of the goals is to reduce estrogen by blocking its conversion from testosterone by taking aromatase inhibitors. Testosterone is produced at the first instance and only then this enzyme changes it to estrogen. Both are very important hormones and the body needs them both. Unnaturally high levels of fat deposits will create an unnatural level of estrogen and will lower testosterone and that will have cascading effects on the rest of the body (1).

It is a condition known as hypogonadism (low testosterone) and it usually comes with old age. One of the longevity treatments for the elderly is something known as testosterone replacement therapy that puts the testosterone levels in the elderly in a range of young adults. This can help with muscle wasting, libido, energy and motivation, bone density, and so on. Having low testosterone for both genders is something everyone will want to avoid.

One of the effect will be an increased risk of cancers that are estrogen responsive such as breast cancer.(2)

fat cells and estrogen and cancer risk
obesity and cancer risk

Also, higher estrogen has a wide range of cascading bad effects for itself. One would be polycystic ovarian syndrome. Having disrupted and out of balance levels of androgenic hormones is not just the question of having acne or bodybuilding. It is a serious health issue that affects the quality of life and can create serious diseases.

Disruption in androgenic hormones will also increase infertility (13). Obesity is associated with subfertility and more than 40% of women seeking obesity surgery do that primarily because they want to have a baby. Infertility in obese patients is correlated to androgen hormone excess on top of insulin resistance. (3)

Fat tissue will also suppress the production of growth hormone (4). Growth hormone deficiency influences a person’s height and helps build bone and muscle. The growth hormone also affects metabolism (the rate at which we burn kilojoules for energy) and will burn fat at a higher rate. One of the strategies of professional athletes is to take a growth hormone to burn fat and build muscle. As for longevity treatment in the elderly, it can also help with a wide range of issues just by itself. A low level of growth hormone can cause a decrease in muscle mass and strength, very low energy levels, reduced bone density, elevated triglyceride levels, and cholesterol, it will affect collagen production and will create dry and thin skin and balding, anxiety and depression, decrease in sexual function.

Fatty liver disease

Obesity is associated with a spectrum of liver abnormalities, known as nonalcoholic fatty liver disease (NAFLD). Most NAFLD patients are asymptomatic on clinical presentation, even though some may present a fatigue, dyspepsia, and dull pain, a general feeling of being unwell and vague discomfort. Treatment for NAFLD involves weight reduction through lifestyle modifications, the anti-obesity medication, and bariatric surgery. It is estimated that 75% of obese individuals are at risk of developing a simple fatty liver. The simple fatty liver is far from a “simple” condition. Up to 23% of obese individuals are at risk of developing fatty liver with inflammation. Almost 10% of children may have NAFLD, due in large part to an alarming increase in childhood obesity. In morbidly obese individuals number is 95%. In the picture, you can see how fat goes internally into the cells of the organs. The liver is swollen due to exercise fat intake. In this case, it is done deliberately by force-feeding with a tube. The practice is known as gavage.

fatty liver
Fatty Liver

lipemic serum
Lipemic Serum

There is also a “spillover” effect where fat cells after a point could not keep all the fat inside them and the fat leeches out to the bloodstream (5). Fat will then interfere with insulin signaling inside the cells and will increase the resistance of the cells to insulin creating diabetes type 2. Higher blood sugar levels will also suppress growth hormone (6). Lipotoxicity also at the same time has the ability to directly kill insulin-producing cells in the pancreas and increase the risk of diabetes type 1 (7).

Joint problems (osteoarthritis)

Knee osteoarthritis in obesity
Knee osteoarthritis in obesity. Colored frontal X-ray of the knees of a 67-year-old obese woman in a standing position. The patient weighs 92 kilograms. The narrowed spacing of the femoro-tibial joints indicates the presence of osteoarthritis. The condition has been caused by the patient’s obesity. Osteoarthritis is a joint disease aggravated by mechanical stress. Symptoms include joint pain, stiffness, and swelling.

Unlike muscle tissue, the cartage is unable to adapt to the ever-increasing load of weight to the same extent. Cartilage cannot grow to become more resilient because in that case the movement would be obstructed. The consequence is that when we have an ever-larger increase of weight gain that is not congruent with our evolution there is a line where the joints are going to take severe damage in time (8). Obese people will have higher pressure on cartilage and it will wear down over time. There is no difference between being forced to carry bags of cement or been forced to carry excessive fat tissue.  There will be physical damage. Then when cartage wears down the inflammation will start or in other words osteoarthritis. Symptoms will include pain, tenderness, swelling, stiffness, grating sensation, loss of flexibility. This is on top of the loss of flexibility that just excessive weight will cause. In cases of morbid obesity, some people are unable to leave the bad and are unable to stand on their own and this is because of weight on top of any issues that might exist due to arthritis. Osteoarthritis is not an autoimmune disease like rheumatoid arthritis and it is caused just by physical damage to the joints. It is the most common form of arthritis. And it is a “one-way street”.

Sleep apnea

sleep apnea
An illustration comparing an obese and normal sleeper. In adults, sleep apnea is commonly caused by excess weight and obesity. During sleep, when the throat and tongue muscles are more relaxed, soft tissue, excess fat deposits, and the weight of abdominal fat pressing on the lungs can interfere with normal sleep.

Excessive pressure will also put a lot of strain on muscle tissue that is responsible for breathing and at the same time will obstruct breathing pathways. The narrowest part of that pathway is in the back of our throat and while we are awake that pathway is relatively open. But when we go to sleep the muscles relax and excessive weight will put pressure on them. That will cause closing by narrowing of the opening. This will interrupt breathing and will lower our oxygen intake basically this is a form of suffocation. This can cause not just snoring but interrupted sleep patterns, cardiovascular disease, and premature death. Especially if there is a combination with some other disease that causes swelling like allergies for example or smoking or taking sedatives. Most of the people that are obese have this to some extent and the real problem is that a big chunk of people will have this for a long time before they realize that they have it.  When you’re awake, muscles keep. But when you sleep, those muscles relax, allowing the opening to narrow. In Western countries prevalence is estimated at around 2% of women and 4% from men (9).

Kidney disease

Why does weight gain affects kidneys is largely unknown. There are theories but so far there is no clear answer. It might be a consequence of increased inflammation and oxidative stress, insulin resistance, and hypertension (10). As fat goes everywhere it will go to the kidney as well and will create damage by raising inflammation. It is known as a fatty kidney (11). The problem with kidneys is that unlike the liver they cannot regenerate themselves. Once the damage is done it will remain for the rest of the life. Having excessive weight will increase the damage and losing weight afterward will not reverse the damage that has already been done. It will also increase the risk of kidney cancer.

Obesity also creates inflammation in the body as a general rule. This means that if we are obese we will have to take a much higher level of antioxidant-rich anti-inflammatory food than someone who is not because we will have a higher level of chronic inflammation that will have a cascading effect and none of them are good. From cancer risk to cardiovascular risk. When inflammation rises the response of the body will be to increase cortisol production by the adrenal glands as it is the main anti-inflammatory hormone of the body. But then that can create high cortisol levels or in other words Cushing’s syndrome. Cortisol is also a stress hormone that puts the body in flight or fight mode and is correlated to different conditions from insomnia, anxiety, and also it is a catabolic hormone that will catabolize muscle mass.  

By now you understand that this is just the list of diseases that are directly associated with just excessive weight gain. In real life, this list should be widened because most people that are obese are not on the whole food plant-based nutrient-rich anti-inflammatory, antioxidant-rich, nutrient-dense diet.

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Sources:

Passages selected from a book: “Go Vegan? Review of Science: Part 1” [Milos Pokimica]

  1. Endocrine Changes in Obesity Sharleen Sidhu, MD, Tanvi Parikh, MD, , and Kenneth D Burman, M.D.
  2. Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention doi: 10.3322/caac.21405
  3. Obesity & osteoarthritis Indian J Med Res. 2013 Aug; 138(2): 185–193.
  4. Growth hormone in obesity. Int J Obes Relat Metab Disord. 1999 Mar;23(3):260-71.
  5. Spillover of Fatty Acids During Dietary Fat Storage in Type 2 Diabetes doi: 10.2337/db12-1407
  6. Effects of growth hormone on glucose metabolism. Horm Res. 1991;36 Suppl 1:32-5.
  7. What Is Lipotoxicity? doi: 10.1007/978-3-319-48382-5_8.
  8. Obesity & osteoarthritis Indian J Med Res. 2013 Aug; 138(2): 185–193
  9. Obesity and Obstructive Sleep Apnea doi: 10.1513/pats.200708-137MG
  10.  Obesity and Kidney Disease doi: 10.1177/2054358117698669
  11.  FATTY KIDNEY, HYPERTENSION, AND CHRONIC KIDNEY DISEASE: THE FRAMINGHAM HEART STUDY doi: 10.1161/HYPERTENSIONAHA.111.175315
  12.  Cortisol, obesity and the metabolic syndrome: A cross-sectional study of obese subjects and review of the literature doi: 10.1002/oby.20083
  13.  Obesity and infertility. Curr Opin Endocrinol Diabetes Obes. 2007 Dec;14(6):482-7.
  14. Obesity and cardiovascular disease in women https://doi.org/10.1038/s41366-020-0548-0

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What the Health is a 2017 documentary film that critiques the health impact of meat, fish, eggs, and dairy products consumption, and questions the practices of leading health and pharmaceutical organizations. Its primary purpose is to advocate for a plant-based diet.
This movie talks about Heart diseases, Diabetes, and other chronic diseases and their relation to the food we eat.
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Directed by: Kip Andersen, Keegan Kuhn
Produced by: Joaquin Phoenix, Kip Andersen, Keegan Kuhn
Written by: Kip Andersen, Keegan Kuhn
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Cinematography: Keegan Kuhn
Edited by: Kip Andersen, Keegan Kuhn, Ali Tabrizi (assistant)
Distributed by: A.U.M. Films & Media
Release date : March 7, 2017 (New York)
Running time: 92 minutes
Country: United States
Language: English

Know Public Health has no rights of this documentary, we just have shared the video for public health interest. All rights go to, Producers and Directors and the media house for this movie.
You can watch this movie on Netflix (www.netflix.com)

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This film is now FREE here on YouTube! Please SHARE this link if you like it. Consider supporting PlantPure - try our plant-based meal starters, which we use to fund a larger social mission, and check out other offerings on our website at PlantPureNation.com. Visit: https://bit.ly/3o11jhY for information on our meal starters and https://bit.ly/2X39uOQ for information on our social mission.

PlantPure Nation tells the story of three people on a quest to spread the message of one of the most important health breakthroughs of all time. After nutritional scientist and author Dr. T. Colin Campbell speaks to the Kentucky legislature, his oldest son Nelson works with Kentucky State Representative Tom Riner to propose a pilot program documenting the health benefits of a plant-based diet. Through this well intentioned effort, they inadvertently set in motion a series of events that expose powerful forces opposed to the diet. After industry lobbyists kill the pilot program, Nelson decides to try his own grassroots approach in his hometown of Mebane, North Carolina, before circling back to Kentucky for a dramatic ending.

A growing number of celebrities, athletes, TV hosts, and nutrition experts have promoted the plant-based diet in the past few years, and tens of thousands of people have documented their personal success stories. But as more doctors and public officials become aware of the healing power of plant-based nutrition the question arises: Why don’t they share the information with the public? Tragically, there have been few official medical or state-sponsored efforts in the nation to support the life sustaining benefits of a whole foods plant-based diet.

PlantPure Nation was filmed across the USA and includes world-renowned experts, doctors and authors. The Production team includes Director Nelson Campbell, and Producer John Corry & Writer Lee Fulkerson from the acclaimed documentary film Forks Over Knives.

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YouTube Video UExXSlpBTjg5dURrWGF0Wkl0aDlDZG55UE1ZcEZ5dUlrbC44QzVGQUU2QjE2NDgxM0M4

PlantPure Nation - The Official FREE YouTube Release

GoVeganWay 737.5K views November 11, 2021 12:45 am

#thegamechangers #netflixmovie #thegamechangersfullmovieinhindi
The Game Changer | Netflix full movie 2019 | The Game Changers Full Movie In Hindi | #thegamechanger #heelupmovie #netflix 


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#thegamechangers #netflixmovie #thegamechangersfullmovieinhindi
The Game Changer | Netflix full movie 2019 | The Game Changers Full Movie In Hindi | #thegamechanger #heelupmovie #netflix


The Game Changer | Netflix Movie | Netflix Documentary on Vegetarian Diet | Diet for Athletes | Virat Kohli Recommended Diet | Netflix Series On Health | Healthy Diet for Sports Person | the game changers netflix | Take Control On your Diet | Healthy Food Diet | Eat vegan | The Game Changers Full Movie | the game changers trailer | the game changers movie in hindi | the game changers hindi | the game changers netflix | the game changers full movie | the game changers documentary | the game changers review | the game changers download | the game changers recipes | heal movie full in hindi | virat kohli documentry | the game changers full movie | game changer | game changer movie |
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the game changers
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1.5K 80

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The Game Changer | Netflix full movie 2019 | The Game Changers Full Movie In Hindi | #thegamechanger

GoVeganWay 94.6K views November 11, 2021 12:45 am

Are we omnivores, carnivores or herbivores? It’s important for animals to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat? Dr. Sofia Pineda Ochoa discusses this often misunderstood topic.

The first part of the transcript is included below for reference, and the full transcript (which is too long to have here) is available on our website, along with sources and credits, at this link: http://meatyourfuture.com/2015/09/herbivores-carnivores/

[The following transcript is an approximation of the audio in  video. To hear the audio and see the accompanying visuals, please play the video.]

PARTIAL TRANSCRIPT:

Are humans herbivores, carnivores or omnivores? It’s very important for a given animal to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat?

When looking at a species to determine what they are in terms of carnivore, omnivore or herbivore, we can look at their behavior or we can look at their biology. From a behavioral standpoint, humans behave as omnivores because we observe many humans in their behavior eating a wide variety of both animal and plant-based foods. Biologically, however, from a physiologic and anatomic standpoint, it’s a different story.

Dr. Williams C. Roberts from the National Institutes of Health and Baylor University — who is the editor-in-chief of the American Journal of Cardiology and one of the most prominent cardiologists in the world with over 1,500 publications in peer reviewed medical journals — summarized our answer very nicely. He wrote:

“Although most of us conduct our lives as omnivores, in that we eat flesh as well as vegetables and fruits, human beings have characteristics of herbivores, not carnivores. The appendages of carnivores are claws; those of herbivores are hands or hooves. The teeth of carnivores are sharp; those of herbivores are mainly flat (for grinding). The intestinal tract of carnivores is short (3 times body length); that of herbivores, long (12 times body length). Body cooling of carnivores is done by panting; herbivores, by sweating. Carnivores drink fluids by lapping; herbivores, by sipping. Carnivores produce their own vitamin C, whereas herbivores obtain it from their diet. Thus, humans have characteristics of herbivores, not carnivores.”

That’s right. Humans have characteristics of herbivores, not carnivores or omnivores — because omnivores, like bears and raccoons, actually retain most of the carnivorous characteristics, so that they are still able to digest and hunt their prey, and do so effectively.

[Remainder of transcript, along with sources and credits, available here: http://meatyourfuture.com/2015/09/herbivores-carnivores]

Are we omnivores, carnivores or herbivores? It’s important for animals to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat? Dr. Sofia Pineda Ochoa discusses this often misunderstood topic.

The first part of the transcript is included below for reference, and the full transcript (which is too long to have here) is available on our website, along with sources and credits, at this link: http://meatyourfuture.com/2015/09/herbivores-carnivores/

[The following transcript is an approximation of the audio in video. To hear the audio and see the accompanying visuals, please play the video.]

PARTIAL TRANSCRIPT:

Are humans herbivores, carnivores or omnivores? It’s very important for a given animal to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat?

When looking at a species to determine what they are in terms of carnivore, omnivore or herbivore, we can look at their behavior or we can look at their biology. From a behavioral standpoint, humans behave as omnivores because we observe many humans in their behavior eating a wide variety of both animal and plant-based foods. Biologically, however, from a physiologic and anatomic standpoint, it’s a different story.

Dr. Williams C. Roberts from the National Institutes of Health and Baylor University — who is the editor-in-chief of the American Journal of Cardiology and one of the most prominent cardiologists in the world with over 1,500 publications in peer reviewed medical journals — summarized our answer very nicely. He wrote:

“Although most of us conduct our lives as omnivores, in that we eat flesh as well as vegetables and fruits, human beings have characteristics of herbivores, not carnivores. The appendages of carnivores are claws; those of herbivores are hands or hooves. The teeth of carnivores are sharp; those of herbivores are mainly flat (for grinding). The intestinal tract of carnivores is short (3 times body length); that of herbivores, long (12 times body length). Body cooling of carnivores is done by panting; herbivores, by sweating. Carnivores drink fluids by lapping; herbivores, by sipping. Carnivores produce their own vitamin C, whereas herbivores obtain it from their diet. Thus, humans have characteristics of herbivores, not carnivores.”

That’s right. Humans have characteristics of herbivores, not carnivores or omnivores — because omnivores, like bears and raccoons, actually retain most of the carnivorous characteristics, so that they are still able to digest and hunt their prey, and do so effectively.

[Remainder of transcript, along with sources and credits, available here: http://meatyourfuture.com/2015/09/herbivores-carnivores]

7.7K 6.4K

YouTube Video UExXSlpBTjg5dURrWGF0Wkl0aDlDZG55UE1ZcEZ5dUlrbC5DRUQwODMxQzUyRTlGRkY3

Are humans omnivores, carnivores or herbivores?

GoVeganWay 351K views September 4, 2021 12:32 am

How much is a human life worth? An innovative cancer therapy promises to save lives. But it is extremely expensive. Will the insurance companies pay for it? What is the manufacturer's return on investment? And do lobbyists drive up prices?

In 2018, the Kymriah gene therapy was approved in Europe. Immune cells are taken from the patient, genetically reprogrammed into cancer killer cells and returned to the patient as an infusion. The results of the Kymriah study only cover a period of 18 months. In 40 percent of patients, lymph gland cancer does not return during this time. It is not clear whether Kymriah has a long-term effect. The Swiss pharmaceutical company Novartis offers the new therapy - it costs 370,000 Swiss francs per patient. Health insurance companies are not usually prepared to pay that much and are complaining about a lack of transparency. 

But the killer cells were not invented in the Novartis laboratories, but at a US university. When Professor Carl June started his research almost 30 years ago, no pharmaceutical company was interested. It was only thanks to funding from tax money and donations that he was able to develop Kymriah at all. After a story went around the world about a girl with leukemia whose cancer disappeared thanks to Kymriah, the pharmaceutical company contacted Novartis and secured exclusive marketing rights. To launch Kymriah on the market, Novartis funded the necessary clinical trials. It's not an isolated incident: Over 60% of newly approved medicines in the US are developed by small biotech companies or universities. Pharmaceutical companies today frequently act as capital providers, cooperating with universities or buying up biotech companies. 

A paradigm shift has taken place in the pharmaceutical industry: Whereas high drug prices used to be justified by research costs, the industry is now using the value of gained lifetime to argue its case. 

 -------------------------------------------------------------------

DW Documentary gives you knowledge beyond the headlines. Watch high-class documentaries from German broadcasters and international production companies. Meet intriguing people, travel to distant lands, get a look behind the complexities of daily life and build a deeper understanding of current affairs and global events. Subscribe and explore the world around you with DW Documentary.

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How much is a human life worth? An innovative cancer therapy promises to save lives. But it is extremely expensive. Will the insurance companies pay for it? What is the manufacturer's return on investment? And do lobbyists drive up prices?

In 2018, the Kymriah gene therapy was approved in Europe. Immune cells are taken from the patient, genetically reprogrammed into cancer killer cells and returned to the patient as an infusion. The results of the Kymriah study only cover a period of 18 months. In 40 percent of patients, lymph gland cancer does not return during this time. It is not clear whether Kymriah has a long-term effect. The Swiss pharmaceutical company Novartis offers the new therapy - it costs 370,000 Swiss francs per patient. Health insurance companies are not usually prepared to pay that much and are complaining about a lack of transparency.

But the killer cells were not invented in the Novartis laboratories, but at a US university. When Professor Carl June started his research almost 30 years ago, no pharmaceutical company was interested. It was only thanks to funding from tax money and donations that he was able to develop Kymriah at all. After a story went around the world about a girl with leukemia whose cancer disappeared thanks to Kymriah, the pharmaceutical company contacted Novartis and secured exclusive marketing rights. To launch Kymriah on the market, Novartis funded the necessary clinical trials. It's not an isolated incident: Over 60% of newly approved medicines in the US are developed by small biotech companies or universities. Pharmaceutical companies today frequently act as capital providers, cooperating with universities or buying up biotech companies.

A paradigm shift has taken place in the pharmaceutical industry: Whereas high drug prices used to be justified by research costs, the industry is now using the value of gained lifetime to argue its case.

-------------------------------------------------------------------

DW Documentary gives you knowledge beyond the headlines. Watch high-class documentaries from German broadcasters and international production companies. Meet intriguing people, travel to distant lands, get a look behind the complexities of daily life and build a deeper understanding of current affairs and global events. Subscribe and explore the world around you with DW Documentary.

Subscribe to:
DW Documentary: https://www.youtube.com/channel/UCW39zufHfsuGgpLviKh297Q?sub_confirmation=1#

DW Documental (Spanish): https://www.youtube.com/dwdocumental
DW Documentary وثائقية دي دبليو: (Arabic): https://www.youtube.com/dwdocarabia

For more visit:
http://www.dw.com/en/tv/docfilm/s-3610
Instagram:
https://www.instagram.com/dwdocumentary/
Facebook:
https://www.facebook.com/dw.stories

DW netiquette policy: https://p.dw.com/p/MF1G

9.2K 1.9K

YouTube Video UExXSlpBTjg5dURrWGF0Wkl0aDlDZG55UE1ZcEZ5dUlrbC41NkI0NEY2RDEwNTU3Q0M2

The power of the pharmaceutical companies | DW Documentary

GoVeganWay 648.6K views September 4, 2021 12:24 am

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