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by Milos Pokimica ND

by Milos Pokimica ND

Learn About Nutrition

Glycogen depletion- How not to exercise

"What happens when we exercise or go on a restrictive diet? What is glycogen depletion and should we avoid it? Does glycogen depletion have any benefits?"

What happens when we exercise or go on a restrictive diet? What is glycogen depletion and should we avoid it? Does glycogen depletion have any benefits?

What happens to the body is that we go into fasting mode (not starving mode). It is a state that is completely different from starvation.

At the first stage, the body will burn readily available calories in the form of stored sugar glycogen. Same as fat our bodies has storage of ready to use sugar (glycogen) that is easily metabolized. It is quick energy that is available in an instant and unlike fat does not require any metabolic pathway. Our cells use glycogen directly.

Most of the sugar is stored primarily in the cells of the liver and the muscles, hydrated with water. When we start to burn more energy than we have available in the bloodstream our blood sugar level is going to drop. At the first stage as a countermeasure, our body is going to use an easily available source of stored energy or in other words stored glycogen. Because glycogen is hydrated with water inside the cells when we burn sugar water molecule is an excess or byproduct of metabolism. Because of that, we will lose some water weight in the first stage.

 If you do not know this, you can be surprised when you go on a diet and lose water and be happy, to gain it all back after. Water loss released from glycogen and sodium is usually the culprit for dramatic first-week weight loss.

In the liver, glycogen reserves can build up to 5–6% of the organ’s flesh weight (100–120 grams in an adult). Muscles have a much lower concentration of glycogen, in the range of one to two percent of the total muscle mass.

The untrained individual holds typically about 400 grams of glycogen that is stored in the entire body, in both muscles and the liver. A trained professional athlete can hold double that amount. This amount of glycogen is enough to last for several hours of intensive exercise without replenishment.

When we train our body adapts, and the condition improves. Professional athletes also do something called carbohydrate loading after the exercises to force their body to adapt by increasing the storage capacity of intramuscular glycogen stores. There are some studies done on this. If we take caffeine or drink coffee glycogen stores tend to be replenished more rapidly.

carb loading meme

Long-distance athletes often experience glycogen depletion. It is called “hitting the wall”. In professional sport, it has a powerful influence because after depleting sugar reserve, fatigue follows and sometimes to the point that it is difficult to move. This is the reason when you see athletes bonking. Bonking (Glycogen depletion) is not the state in which you are just feeling tired. Bonking is when your glycogen reserve stores get so low that your brain starts to run out of energy and then shuts your body down.

bonking
Bonking (Glycogen depletion)

After the initial stage and metabolization of easily available reserves of glycogen, the liver will begin to break down fat and protein to form energy immediately. The problem is that this process takes time and until gluconeogenesis kicks in, an athlete may experience symptoms of hypoglycemia. If this happens, it will not be uncommon to see professional athletes collapse from extreme fatigue.

Hypoglycemia comes with dizziness, blurred vision, hallucinations. Loss of consciousness may also occur under these conditions. The combined use of several different energy sources that allow extended high muscular power outputs that can be maintained for an extended period is a big deal in professional sport and research. Also, no we cannot go on a diet before the marathon to tap to gluconeogenesis and then run. Running a marathon using fat alone as a fuel source is not plausible. If we are able to metabolize fat at a higher rate then we would never become tired and could run indefinitely. The energy efficiency of fat metabolization, unfortunately, is not at that level.

Moreover, our body can only process a limited amount of carbohydrates per hour also, around 30-60 grams depending on individual efficiency. You probably won’t race a marathon, but it is essential to understand how the body works if you want to exercise, you can potentially do yourself damage, or don’t get the desired results.

Runner Hitting The Wall
Hitting The Wall

In bodybuilding, it is a big deal also because catabolizing muscle mass for energy is not the desired course. After glycogen depletion from 16 hours to 72 hours, the body will lean heavily on amino acids and protein catabolism for energy creation. Amino acids will be used, and some of the muscle mass will be lost when going on a fast with or without exercise. We can try to minimize it, but some amino acids will be used for energy.

The loss of some of the tissue is not as bad as it sounds. It has an evolutional purpose and health benefits if done moderately. It is normal for all animals including humans to go into fasting mode periodically. Our bodies have adapted to fasting during evolution in the same way that we have adapted to physical activity. Moderate periodical fasting will help our body to clean its mutated and damaged precancerous cells in a process known as autophagy (self-eating). When there are two cells and one is damaged and one has to be destroyed for energy, the body will catabolize damaged cells first and thus clean itself in a sense. We will have a negative impact on our health if we do not incorporate exercise and fasting in our regular life.

After this initial period, our metabolism will shift to ketosis where it gets almost all of its energy from ketone bodies from fat metabolism. The basal metabolic rate will drop also, or in other words, the use of energy will become more efficient. If you want to diet this is a state you would want to be in. A permanent caloric deficit in the amount that you can handle. Running a marathon or doing extensive exercise in a fasted state might not be so beneficial because our brain will be left without food and will be forced to use our own muscle tissue for energy. This is not the desired outcome.

We can last to a period of 2.5 to 3 months just drinking water depending on how much fat we have to begin with. If we have large amounts of fat, we can last much longer, but nutrient deficiencies will occur. Because of this reason low-calorie nutrient-dense, whole fiber-rich food is a base for every diet.  

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Sources:

Passages selected from a book: “Go Vegan? Review of Science: Part 1” [Milos Pokimica]

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GoVeganWay.com brings you reviews of the latest nutrition and health-related research. The information provided represents the personal opinion of the author and is not intended nor implied to be a substitute for professional medical advice, diagnosis, or treatment.  The information provided is for informational purposes only and is not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider.

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Distributed by: A.U.M. Films & Media
Release date : March 7, 2017 (New York)
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Country: United States
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Know Public Health has no rights of this documentary, we just have shared the video for public health interest. All rights go to, Producers and Directors and the media house for this movie.
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Our (Know Public Health) vision is to make available of Public Health Awareness and knowledge/study materials to the general public from all over so that you can easily get access to the contents. You can visit our website ( www.knowpublichealth.com )
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Are we omnivores, carnivores or herbivores? It’s important for animals to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat? Dr. Sofia Pineda Ochoa discusses this often misunderstood topic.

The first part of the transcript is included below for reference, and the full transcript (which is too long to have here) is available on our website, along with sources and credits, at this link: http://meatyourfuture.com/2015/09/herbivores-carnivores/

[The following transcript is an approximation of the audio in  video. To hear the audio and see the accompanying visuals, please play the video.]

PARTIAL TRANSCRIPT:

Are humans herbivores, carnivores or omnivores? It’s very important for a given animal to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat?

When looking at a species to determine what they are in terms of carnivore, omnivore or herbivore, we can look at their behavior or we can look at their biology. From a behavioral standpoint, humans behave as omnivores because we observe many humans in their behavior eating a wide variety of both animal and plant-based foods. Biologically, however, from a physiologic and anatomic standpoint, it’s a different story.

Dr. Williams C. Roberts from the National Institutes of Health and Baylor University — who is the editor-in-chief of the American Journal of Cardiology and one of the most prominent cardiologists in the world with over 1,500 publications in peer reviewed medical journals — summarized our answer very nicely. He wrote:

“Although most of us conduct our lives as omnivores, in that we eat flesh as well as vegetables and fruits, human beings have characteristics of herbivores, not carnivores. The appendages of carnivores are claws; those of herbivores are hands or hooves. The teeth of carnivores are sharp; those of herbivores are mainly flat (for grinding). The intestinal tract of carnivores is short (3 times body length); that of herbivores, long (12 times body length). Body cooling of carnivores is done by panting; herbivores, by sweating. Carnivores drink fluids by lapping; herbivores, by sipping. Carnivores produce their own vitamin C, whereas herbivores obtain it from their diet. Thus, humans have characteristics of herbivores, not carnivores.”

That’s right. Humans have characteristics of herbivores, not carnivores or omnivores — because omnivores, like bears and raccoons, actually retain most of the carnivorous characteristics, so that they are still able to digest and hunt their prey, and do so effectively.

[Remainder of transcript, along with sources and credits, available here: http://meatyourfuture.com/2015/09/herbivores-carnivores]

Are we omnivores, carnivores or herbivores? It’s important for animals to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat? Dr. Sofia Pineda Ochoa discusses this often misunderstood topic.

The first part of the transcript is included below for reference, and the full transcript (which is too long to have here) is available on our website, along with sources and credits, at this link: http://meatyourfuture.com/2015/09/herbivores-carnivores/

[The following transcript is an approximation of the audio in video. To hear the audio and see the accompanying visuals, please play the video.]

PARTIAL TRANSCRIPT:

Are humans herbivores, carnivores or omnivores? It’s very important for a given animal to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat?

When looking at a species to determine what they are in terms of carnivore, omnivore or herbivore, we can look at their behavior or we can look at their biology. From a behavioral standpoint, humans behave as omnivores because we observe many humans in their behavior eating a wide variety of both animal and plant-based foods. Biologically, however, from a physiologic and anatomic standpoint, it’s a different story.

Dr. Williams C. Roberts from the National Institutes of Health and Baylor University — who is the editor-in-chief of the American Journal of Cardiology and one of the most prominent cardiologists in the world with over 1,500 publications in peer reviewed medical journals — summarized our answer very nicely. He wrote:

“Although most of us conduct our lives as omnivores, in that we eat flesh as well as vegetables and fruits, human beings have characteristics of herbivores, not carnivores. The appendages of carnivores are claws; those of herbivores are hands or hooves. The teeth of carnivores are sharp; those of herbivores are mainly flat (for grinding). The intestinal tract of carnivores is short (3 times body length); that of herbivores, long (12 times body length). Body cooling of carnivores is done by panting; herbivores, by sweating. Carnivores drink fluids by lapping; herbivores, by sipping. Carnivores produce their own vitamin C, whereas herbivores obtain it from their diet. Thus, humans have characteristics of herbivores, not carnivores.”

That’s right. Humans have characteristics of herbivores, not carnivores or omnivores — because omnivores, like bears and raccoons, actually retain most of the carnivorous characteristics, so that they are still able to digest and hunt their prey, and do so effectively.

[Remainder of transcript, along with sources and credits, available here: http://meatyourfuture.com/2015/09/herbivores-carnivores]

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Are humans omnivores, carnivores or herbivores?

GoVeganWay 351K views September 4, 2021 12:32 am

How much is a human life worth? An innovative cancer therapy promises to save lives. But it is extremely expensive. Will the insurance companies pay for it? What is the manufacturer's return on investment? And do lobbyists drive up prices?

In 2018, the Kymriah gene therapy was approved in Europe. Immune cells are taken from the patient, genetically reprogrammed into cancer killer cells and returned to the patient as an infusion. The results of the Kymriah study only cover a period of 18 months. In 40 percent of patients, lymph gland cancer does not return during this time. It is not clear whether Kymriah has a long-term effect. The Swiss pharmaceutical company Novartis offers the new therapy - it costs 370,000 Swiss francs per patient. Health insurance companies are not usually prepared to pay that much and are complaining about a lack of transparency. 

But the killer cells were not invented in the Novartis laboratories, but at a US university. When Professor Carl June started his research almost 30 years ago, no pharmaceutical company was interested. It was only thanks to funding from tax money and donations that he was able to develop Kymriah at all. After a story went around the world about a girl with leukemia whose cancer disappeared thanks to Kymriah, the pharmaceutical company contacted Novartis and secured exclusive marketing rights. To launch Kymriah on the market, Novartis funded the necessary clinical trials. It's not an isolated incident: Over 60% of newly approved medicines in the US are developed by small biotech companies or universities. Pharmaceutical companies today frequently act as capital providers, cooperating with universities or buying up biotech companies. 

A paradigm shift has taken place in the pharmaceutical industry: Whereas high drug prices used to be justified by research costs, the industry is now using the value of gained lifetime to argue its case. 

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How much is a human life worth? An innovative cancer therapy promises to save lives. But it is extremely expensive. Will the insurance companies pay for it? What is the manufacturer's return on investment? And do lobbyists drive up prices?

In 2018, the Kymriah gene therapy was approved in Europe. Immune cells are taken from the patient, genetically reprogrammed into cancer killer cells and returned to the patient as an infusion. The results of the Kymriah study only cover a period of 18 months. In 40 percent of patients, lymph gland cancer does not return during this time. It is not clear whether Kymriah has a long-term effect. The Swiss pharmaceutical company Novartis offers the new therapy - it costs 370,000 Swiss francs per patient. Health insurance companies are not usually prepared to pay that much and are complaining about a lack of transparency.

But the killer cells were not invented in the Novartis laboratories, but at a US university. When Professor Carl June started his research almost 30 years ago, no pharmaceutical company was interested. It was only thanks to funding from tax money and donations that he was able to develop Kymriah at all. After a story went around the world about a girl with leukemia whose cancer disappeared thanks to Kymriah, the pharmaceutical company contacted Novartis and secured exclusive marketing rights. To launch Kymriah on the market, Novartis funded the necessary clinical trials. It's not an isolated incident: Over 60% of newly approved medicines in the US are developed by small biotech companies or universities. Pharmaceutical companies today frequently act as capital providers, cooperating with universities or buying up biotech companies.

A paradigm shift has taken place in the pharmaceutical industry: Whereas high drug prices used to be justified by research costs, the industry is now using the value of gained lifetime to argue its case.

-------------------------------------------------------------------

DW Documentary gives you knowledge beyond the headlines. Watch high-class documentaries from German broadcasters and international production companies. Meet intriguing people, travel to distant lands, get a look behind the complexities of daily life and build a deeper understanding of current affairs and global events. Subscribe and explore the world around you with DW Documentary.

Subscribe to:
DW Documentary: https://www.youtube.com/channel/UCW39zufHfsuGgpLviKh297Q?sub_confirmation=1#

DW Documental (Spanish): https://www.youtube.com/dwdocumental
DW Documentary وثائقية دي دبليو: (Arabic): https://www.youtube.com/dwdocarabia

For more visit:
http://www.dw.com/en/tv/docfilm/s-3610
Instagram:
https://www.instagram.com/dwdocumentary/
Facebook:
https://www.facebook.com/dw.stories

DW netiquette policy: https://p.dw.com/p/MF1G

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The power of the pharmaceutical companies | DW Documentary

GoVeganWay 648.6K views September 4, 2021 12:24 am

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