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by Milos Pokimica ND

by Milos Pokimica ND

Learn About Nutrition

Lectins- Paradox of the “Plant Paradox”

"The paradox of the “Plant Paradox” is that people who eat more lectins (beans and whole grains) have less cancer."

The paradox of “Plant Paradox” is that people who eat more lectins (beans and whole grains) have less cancer.

There is always some “evil” and some reason why people should avoid eating the whole plant-based food diet and usually, these types of books are well received and well-promoted by mainstream media. After reading the book “Plant Paradox” someone might get the idea that eating raw plant foods might get him sick because of the antinutrients and that best thing is to avoid this type of toxins like lectins. Go with a high protein lean meat, right, healthy fats like fish.

The truth is that the food is usually design to be eaten raw by nature itself. Eating raw vegetables is better than cooked but eating raw beans, for example, can kill you dead. Five raw dried red kidney beans are enough to cause vomiting diarrhea and pain. That is because the substances called lectins, chemicals that paleo diet people find to be one of the root causes of all evil.

The Plant Paradox Book

To some extent, they can be right. Lectins are a family of proteins that bind to carbohydrates. They are sugar-binding and convert to the glyco portion of glycoconjugates in the cell membranes. The main constituents of human cell membranes include lipids, glycoproteins, lipid-linked proteins, and proteins. So they are in all of us. Lectins are proven to play a different role in cell growth, cell death, body fat regulation, and immune functions. Some of them no one should be consuming ever. However, some of them are necessary.

Since plants cannot move, they use their natural chemistry to protect themselves from microorganisms, insects, and other animals. One of the defensive chemicals is lectins. They are not to be confused with leptin, which is a satiety peptide hormone produced almost exclusively in fat tissue. Lectins play a role in different biological systems. Not just in the human body but also in animals, plants, bacteria, and even viruses. Some are toxic, inflammatory, or both and can have anti-nutrient value. They can block the absorption of some nutrients. Some are beneficial and have anti-cancerogenic activity. There is a wide variety of them.

Most of them are destroyed by cooking, but some are resistant to cooking and digestive enzymes, but again some of them are destroyed by sprouting. In nature seeds have to stay fresh and ready to sprout so naturally in the seed there are chemicals that will kill all of the putrefying bacteria. These chemicals can be deactivated by soaking, which is the beginning of the sprouting. When the seed starts to sprout it neutralizes its protective preservative chemicals that can have ant nutrient and toxic effect.

Avoiding lectins is not possible or almost impossible because they are present in all of our food. They are abundant in raw legumes and grains and in some vegetables, but the more problematic lectins are found primarily in the legumes. Some in wheat can also be problematic.

celiac disease
Celiac disease
Gliadin IGA
Gliadin IGA

Wheat gliadin, which causes coeliac disease, is a lectin-like substance and it binds to the human intestinal mucosa. Gliadin has been theorized as the coeliac disease toxin for over 20 years. Because we do not digest lectins, they passed into our blood circulation, so we often produce antibodies to them. Everyone has some antibodies to some dietary lectins. The appearance of different lectins can stimulate an immune system response. However, depending on the individual, the response can vary. In some individuals, some types of foods can become intolerable after the immune system change or after the permeability of the intestinal line increase so the immune system response will have to increase as well.

lectin leaky gut
Leaky gut

If we have developed antibodies to them that can be a problem not because of the lectin itself but because of something called molecular mimicry. And that can be a real nightmare. If some chemical gets to our bloodstream and our immune system makes antibody to that chemical and if the chemical is similar to some of our own cells, meaning it has a sequence of amino acids that are the same as the sequence in some of our own cells, then the bad things are going to happen. After cleaning the evil intruder chemical, the antibody will detect our own cell as the same chemical and will attack our own living tissue eating us from the inside. When the immune system by mistake of molecular mimicry starts to attack our own cells, the horrors of never curable autoimmune disease begins.

molecular mimicry
Molecular Mimicry

The great news is that lectins are not similar genetically to us because they are from the plant kingdom that has different cells than our own and will not cause autoimmune reactions. However, it still can cause allergies and inflammation. Many lectins are potent allergens. For instance, prohevein is the primary allergen of rubber latex. In recent years, a new strain of genetically modified tomatoes has been created that have added genes for the production of prohevein because of its fungistatic properties. Because of this in the future, we can expect a rise in tomato allergies among latex-sensitive individuals.

Of specific interest is the fact that lectins can stimulate class II HL antigens on cells that do not usually display them, such as pancreatic islet and thyroid cells. Insulin-dependent diabetes, therefore, can be a potential lectin disease. Another possible correlation to a lectin disease is rheumatoid arthritis. In diet-responsive rheumatoid arthritis, one of the most typical trigger foods is wheat. Some of the effects observed in the small intestine in rodents was stripping away of the mucous coat and exposing naked mucosa to abnormal bacteria growth. Lectins also stimulate acid secretion by causing a release of histamine from gastric mast cells. Three central pathogenic constituents for peptic ulcer, stripping away of the mucous defense layer, abnormal bacterial proliferation (Helicobacter pylori), then release of histamine and acid stimulation are all theoretically linked to lectins.

However, if we all eat lectins, why don’t we all get peptic ulcers, rheumatoid arthritis, and insulin-dependent diabetes? Partially because cells are preserved behind a fine screen of sialic acid molecules and partially because of natural change in the glycoconjugates that coat our cells. However, the sialic acid molecules can be stripped off by the enzyme called neuraminidase, present in several micro-organisms such as streptococci and influenza viruses. This may reveal why diabetes and rheumatoid arthritis tend to occur as a sequence of infections. The best thing to do when you are sick is to listen to your body not your mom and do not eat.

What can happen that is potentially dangerous is the situation when lectins affect the gut wall, and we eat food from the animal kingdom that is genetically similar to our own cells. Lectins can cause inflammation and create damage to the lining of the intestines. If this damage is not regenerated fast enough, the gut can become leaky allowing various molecules (including stuff we do not want) to pass into the bloodstream and that is one of the main factors that are responsible for the creation of autoimmune diseases.

In normal situations for most people, lectin inflammation usually is not at the level that is dangerous and should not be the problem but if you have an allergy to some of the lectins, then it might. The brain is the brain, muscle is a muscle, sort of speak, so if at the same time we have leaky gut and eat animal tissue, the autoimmune diseases are theoretically possible especially because of our low level of stomach acidity that cannot dissolve animal protein completely. Globular undigested proteins from animal tissue similar to our own tissue entering our bloodstream because of the lectin inflammation in the gut are a recipe for autoimmune diseases. The only thing that is normal is individual amino acids passing thru, if we have more amino acids in the chain in the blood then it is a potential invader swimming around and the immune system steps into action.

For people with leaky gut, Crohn’s disease, and any type of problem with digestion eating animal protein is in my opinion one leg in the grave. True carnivore with stomach acidity of pH one does not have to worry about this. Also when enough lectins are consumed, it can signal our body to evacuate GI contents. This means vomiting, cramping, and diarrhea. It may further induce a comprehensive immune system response creating inflammation as the body’s defenses move in to attack the invaders.

Inflammation small and large intestine
Inflammation small and large intestine

If you eat animal protein or even if you do not, it is a good idea to do allergic testing for every type of food early in childhood because food allergies can cascade into the leaky gut, then into autoimmune diseases like diabetes type 1 or multiple sclerosis.

The worst and the most famous lectin is ricin produced in the seeds of the castor oil plant, Ricinus communis. Ricin was even used in an experimental military chemical warfare program during World War 1. There was an attempt to make coating bullets and ricin bombs, but the program did not prove to be particularly useful. It takes precisely 1.78mg of ricin to kill an average adult person. It can even be inhaled. That is about the same amount as few grains of table salt which ricin resembles visually. It is untraceable in toxicology examinations because the poison is just a catalyst that will start a chain reaction in the body. When the first symptoms begin to show the ricin is already destroyed and cannot be detected in the body. It is at least ten times more toxic than the most potent nerve gas. A 1% water solution with an explosive burster has the same effectiveness as sarin nerve gas. That is the power of the plants. The only disadvantage ricin has is the time it needs for the victims to die. It will not have the quick tactical effect of nerve gas like sarin if you use it in combat, so it was abandoned as a military weapon. However, for single covert assassinations, it is a useful substance because the assassin can escape long before the first symptoms of poisoning had been detected. Bulgarian dissident Georgi Markov was killed in this way back in 1978 in the middle of the street in London by stabbing him from behind with an umbrella. The weaponized umbrella had ricin, and when he was stabbed in the leg with it, it was game over. He died four days later. There is no antidote currently available for ricin poisoning, only some experimental stuff that is not available to the public and not very reliable because the antidote only works while ricin is still in the blood. Usually when the first symptoms start it is already too late. If exposed death is guaranteed. Only vaccination is possible and only is effective for several months by injecting an inactive form of the protein chain.

ricin letter
Ricin Letter

Breaking Bad series actually had inspired several real-life criminal cases involving ricin poisoning. The US government has done everything it can to hide copies of this deadly poison, but in reality, I was able to find one in a couple of minutes. Castor oil seeds contain around 5-10 percent ricin. You just have to remove the oil and fiber and filter it out. Even five to ten raw ground castor seeds will kill an adult human without making the poison. And yes castor oil is perfectly safe, according to the FDA and your grandma, ricin is not in castor oil. When we know about stuff like this, it is easy to spread hysteria about lectins like the book Plant Paradox and other bad science made to sell lectin shield products and diets. Also, lectins in the diet are not blood-type specific, so the blood type diet is just wrong. It reminds me of the gluten story. Lectin avoidance can become a new gluten scam. While many types of lectins are dangerous, there are also health-promoting lectins that can decrease the incidence of certain diseases.

Furthermore, they are necessary for some of the essential biochemical processes in which the body uses lectins to achieve many essential functions, including programmed cell death, inflammatory modulation, and cell to cell adherence. The ones that can cause problems are the ones in beans and if you have food allergies and that is it. Actually low doses of lectins are beneficial by ameliorating obesity, limiting tumor growth, and stimulating gut function. Especially for colon cancer. Ricin itself has been under several experiments as a new drug for cancer treatment. There are lectins that kill cancer cells and at the same time don’t do anything to normal cells. There are even lectins that force mutagenic cancer cells to go back into regular ones without killing them. The interest started back in 1963 after the discovery that lectins can distinguish between normal and malignant cells. Lectins are so specific that a stool sample can predict the presence of polyps and cancers on the basis of lectin binding to the colon lining cells. In a Petri dish, they have so far been able to kill a wide variety of cancers.

Because most of the lectins are in the intestines the benefits for colorectal cancer are the highest because most of them will come into contact with colon cells before they are absorbed. Big pharma currently researches different lectins, and it is expected that in the future there will be lectin-based drugs. When we look at studies, dietary consumption of beans has been correlated to lower risk of colorectal cancer, diabetes risk, and mortality from all cases. Consumption of whole grains had been correlated with reduced risk of heart disease, strokes, diabetes, cancer, and mortality from all causes. The same story with other high lectin whole foods. If you are not allergic eating tomatoes or whole grains or beans will actually reduce the overall inflammation in the body even with all of the inflammatory lectins in them. Only legumes are poisonous when raw.

So how do we remove the lectins from the beans?

If beans are soaked for 5 hours, then 15 minutes of cooking will completely eliminate all lectins in them. If you use a pressure cooker, then the time is under 8 minutes. Before the beans are palatable, the lectins would be long gone. If beans are not soaked, then around 45 minutes of pressure cooking will eliminate them but still, they will be palatable after 60 minutes. At any rate, the beans would be free from all lectins if palatable no matter what way we cooked them. One important note, lectins are to some degree resistant to dry heat such as what would occur in baking. Cooking with legume flower that is not soaked and cooked first is not a traditional way but also not prudent or smart. The second line of defense against lectins is plain carbohydrates because lectins bind to them instantly. The minor quantities of lectins left after soaking and cooking bind with free carbs in the foods and are effectively deactivated. Only individuals eating a raw diet with certain acute or chronic infections like leaky gut or other conditions may find that lectin minimization is necessary but even in their case it might not be. Lectins are here to stay, but there are some other types of natural toxins besides lectins that we should try to minimize.

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Sources:

Passages selected from a book: “Go Vegan? Review of Science: Part 1” [Milos Pokimica]

  1. Whole Grain Consumption and Risk of Cardiovascular Disease, Cancer, and All Cause and Cause Specific Mortality: Systematic Review and Dose-Response Meta-Analysis of Prospective Studies doi: 10.1136/bmj.i2716
  2. Dietary Legume Consumption Reduces Risk of Colorectal Cancer: Evidence From a Meta-Analysis of Cohort Studies doi: 10.1038/srep08797
  3. Health effects of wheat lectins: A review https://doi.org/10.1016/j.jcs.2014.01.010
  4. White Kidney Bean Lectin Exerts Anti-Proliferative and Apoptotic Effects on Cancer Cells doi: 10.1016/j.ijbiomac.2015.12.094
  5. Lectins as Bioactive Plant Proteins: A Potential in Cancer Treatment doi: 10.1080/10408390591034445
  6. Dietary Lectins as Disease Causing Toxicants doi: 10.3923/pjn.2009.293.303

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Distributed by: A.U.M. Films & Media
Release date : March 7, 2017 (New York)
Running time: 92 minutes
Country: United States
Language: English

Know Public Health has no rights of this documentary, we just have shared the video for public health interest. All rights go to, Producers and Directors and the media house for this movie.
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1.5K 80

YouTube Video UExXSlpBTjg5dURrWGF0Wkl0aDlDZG55UE1ZcEZ5dUlrbC5ENjI1QUI0MDI5NEQzODFE

The Game Changer | Netflix full movie 2019 | The Game Changers Full Movie In Hindi | #thegamechanger

GoVeganWay 94.6K views November 11, 2021 12:45 am

Are we omnivores, carnivores or herbivores? It’s important for animals to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat? Dr. Sofia Pineda Ochoa discusses this often misunderstood topic.

The first part of the transcript is included below for reference, and the full transcript (which is too long to have here) is available on our website, along with sources and credits, at this link: http://meatyourfuture.com/2015/09/herbivores-carnivores/

[The following transcript is an approximation of the audio in  video. To hear the audio and see the accompanying visuals, please play the video.]

PARTIAL TRANSCRIPT:

Are humans herbivores, carnivores or omnivores? It’s very important for a given animal to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat?

When looking at a species to determine what they are in terms of carnivore, omnivore or herbivore, we can look at their behavior or we can look at their biology. From a behavioral standpoint, humans behave as omnivores because we observe many humans in their behavior eating a wide variety of both animal and plant-based foods. Biologically, however, from a physiologic and anatomic standpoint, it’s a different story.

Dr. Williams C. Roberts from the National Institutes of Health and Baylor University — who is the editor-in-chief of the American Journal of Cardiology and one of the most prominent cardiologists in the world with over 1,500 publications in peer reviewed medical journals — summarized our answer very nicely. He wrote:

“Although most of us conduct our lives as omnivores, in that we eat flesh as well as vegetables and fruits, human beings have characteristics of herbivores, not carnivores. The appendages of carnivores are claws; those of herbivores are hands or hooves. The teeth of carnivores are sharp; those of herbivores are mainly flat (for grinding). The intestinal tract of carnivores is short (3 times body length); that of herbivores, long (12 times body length). Body cooling of carnivores is done by panting; herbivores, by sweating. Carnivores drink fluids by lapping; herbivores, by sipping. Carnivores produce their own vitamin C, whereas herbivores obtain it from their diet. Thus, humans have characteristics of herbivores, not carnivores.”

That’s right. Humans have characteristics of herbivores, not carnivores or omnivores — because omnivores, like bears and raccoons, actually retain most of the carnivorous characteristics, so that they are still able to digest and hunt their prey, and do so effectively.

[Remainder of transcript, along with sources and credits, available here: http://meatyourfuture.com/2015/09/herbivores-carnivores]

Are we omnivores, carnivores or herbivores? It’s important for animals to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat? Dr. Sofia Pineda Ochoa discusses this often misunderstood topic.

The first part of the transcript is included below for reference, and the full transcript (which is too long to have here) is available on our website, along with sources and credits, at this link: http://meatyourfuture.com/2015/09/herbivores-carnivores/

[The following transcript is an approximation of the audio in video. To hear the audio and see the accompanying visuals, please play the video.]

PARTIAL TRANSCRIPT:

Are humans herbivores, carnivores or omnivores? It’s very important for a given animal to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat?

When looking at a species to determine what they are in terms of carnivore, omnivore or herbivore, we can look at their behavior or we can look at their biology. From a behavioral standpoint, humans behave as omnivores because we observe many humans in their behavior eating a wide variety of both animal and plant-based foods. Biologically, however, from a physiologic and anatomic standpoint, it’s a different story.

Dr. Williams C. Roberts from the National Institutes of Health and Baylor University — who is the editor-in-chief of the American Journal of Cardiology and one of the most prominent cardiologists in the world with over 1,500 publications in peer reviewed medical journals — summarized our answer very nicely. He wrote:

“Although most of us conduct our lives as omnivores, in that we eat flesh as well as vegetables and fruits, human beings have characteristics of herbivores, not carnivores. The appendages of carnivores are claws; those of herbivores are hands or hooves. The teeth of carnivores are sharp; those of herbivores are mainly flat (for grinding). The intestinal tract of carnivores is short (3 times body length); that of herbivores, long (12 times body length). Body cooling of carnivores is done by panting; herbivores, by sweating. Carnivores drink fluids by lapping; herbivores, by sipping. Carnivores produce their own vitamin C, whereas herbivores obtain it from their diet. Thus, humans have characteristics of herbivores, not carnivores.”

That’s right. Humans have characteristics of herbivores, not carnivores or omnivores — because omnivores, like bears and raccoons, actually retain most of the carnivorous characteristics, so that they are still able to digest and hunt their prey, and do so effectively.

[Remainder of transcript, along with sources and credits, available here: http://meatyourfuture.com/2015/09/herbivores-carnivores]

7.7K 6.4K

YouTube Video UExXSlpBTjg5dURrWGF0Wkl0aDlDZG55UE1ZcEZ5dUlrbC5DRUQwODMxQzUyRTlGRkY3

Are humans omnivores, carnivores or herbivores?

GoVeganWay 351K views September 4, 2021 12:32 am

How much is a human life worth? An innovative cancer therapy promises to save lives. But it is extremely expensive. Will the insurance companies pay for it? What is the manufacturer's return on investment? And do lobbyists drive up prices?

In 2018, the Kymriah gene therapy was approved in Europe. Immune cells are taken from the patient, genetically reprogrammed into cancer killer cells and returned to the patient as an infusion. The results of the Kymriah study only cover a period of 18 months. In 40 percent of patients, lymph gland cancer does not return during this time. It is not clear whether Kymriah has a long-term effect. The Swiss pharmaceutical company Novartis offers the new therapy - it costs 370,000 Swiss francs per patient. Health insurance companies are not usually prepared to pay that much and are complaining about a lack of transparency. 

But the killer cells were not invented in the Novartis laboratories, but at a US university. When Professor Carl June started his research almost 30 years ago, no pharmaceutical company was interested. It was only thanks to funding from tax money and donations that he was able to develop Kymriah at all. After a story went around the world about a girl with leukemia whose cancer disappeared thanks to Kymriah, the pharmaceutical company contacted Novartis and secured exclusive marketing rights. To launch Kymriah on the market, Novartis funded the necessary clinical trials. It's not an isolated incident: Over 60% of newly approved medicines in the US are developed by small biotech companies or universities. Pharmaceutical companies today frequently act as capital providers, cooperating with universities or buying up biotech companies. 

A paradigm shift has taken place in the pharmaceutical industry: Whereas high drug prices used to be justified by research costs, the industry is now using the value of gained lifetime to argue its case. 

 -------------------------------------------------------------------

DW Documentary gives you knowledge beyond the headlines. Watch high-class documentaries from German broadcasters and international production companies. Meet intriguing people, travel to distant lands, get a look behind the complexities of daily life and build a deeper understanding of current affairs and global events. Subscribe and explore the world around you with DW Documentary.

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How much is a human life worth? An innovative cancer therapy promises to save lives. But it is extremely expensive. Will the insurance companies pay for it? What is the manufacturer's return on investment? And do lobbyists drive up prices?

In 2018, the Kymriah gene therapy was approved in Europe. Immune cells are taken from the patient, genetically reprogrammed into cancer killer cells and returned to the patient as an infusion. The results of the Kymriah study only cover a period of 18 months. In 40 percent of patients, lymph gland cancer does not return during this time. It is not clear whether Kymriah has a long-term effect. The Swiss pharmaceutical company Novartis offers the new therapy - it costs 370,000 Swiss francs per patient. Health insurance companies are not usually prepared to pay that much and are complaining about a lack of transparency.

But the killer cells were not invented in the Novartis laboratories, but at a US university. When Professor Carl June started his research almost 30 years ago, no pharmaceutical company was interested. It was only thanks to funding from tax money and donations that he was able to develop Kymriah at all. After a story went around the world about a girl with leukemia whose cancer disappeared thanks to Kymriah, the pharmaceutical company contacted Novartis and secured exclusive marketing rights. To launch Kymriah on the market, Novartis funded the necessary clinical trials. It's not an isolated incident: Over 60% of newly approved medicines in the US are developed by small biotech companies or universities. Pharmaceutical companies today frequently act as capital providers, cooperating with universities or buying up biotech companies.

A paradigm shift has taken place in the pharmaceutical industry: Whereas high drug prices used to be justified by research costs, the industry is now using the value of gained lifetime to argue its case.

-------------------------------------------------------------------

DW Documentary gives you knowledge beyond the headlines. Watch high-class documentaries from German broadcasters and international production companies. Meet intriguing people, travel to distant lands, get a look behind the complexities of daily life and build a deeper understanding of current affairs and global events. Subscribe and explore the world around you with DW Documentary.

Subscribe to:
DW Documentary: https://www.youtube.com/channel/UCW39zufHfsuGgpLviKh297Q?sub_confirmation=1#

DW Documental (Spanish): https://www.youtube.com/dwdocumental
DW Documentary وثائقية دي دبليو: (Arabic): https://www.youtube.com/dwdocarabia

For more visit:
http://www.dw.com/en/tv/docfilm/s-3610
Instagram:
https://www.instagram.com/dwdocumentary/
Facebook:
https://www.facebook.com/dw.stories

DW netiquette policy: https://p.dw.com/p/MF1G

9.2K 1.9K

YouTube Video UExXSlpBTjg5dURrWGF0Wkl0aDlDZG55UE1ZcEZ5dUlrbC41NkI0NEY2RDEwNTU3Q0M2

The power of the pharmaceutical companies | DW Documentary

GoVeganWay 648.6K views September 4, 2021 12:24 am

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