Optimal Human Diet- Chronic Diseases, Diet Wars, and the Vegan Argument
Our natural optimal human diet is a diet that our hominin ancestors were eating for the last 30 million years, not anatomically modern humans in the Stone age.
Milos Pokimica
Written By: Milos Pokimica
Medically Reviewed by: Dr. Xiùying Wáng, M.D.
Updated August 4, 2023An optimal human diet is a basis for optimal health. When we look at the list of 15 leading causes of death more than 80% are lifestyle influenced. They are caused by our bad diet. In most cases, the disease is a choice.
It is not a bad genetic that gives us disease and that is a big open secret. For example, cancer is a preventable lifestyle disease. Real genetic causes are responsible for no more than 5% of all deaths. More than 85% of people die because of their bad diet.
Think about it this way. If you are born with the disease and it is a serious life-threatening condition, you will have to take your medications and manage your condition the best way you could. Problem is that just 100 years ago there was no insulin, chemotherapy, antibiotics, or any other medicine available. Any disease that will require any form of treatment was life-threatening and as a consequence would be selected against. In evolutionary terms, there would never be a statistically significant number of people from the overall population that has these forms of chronic diseases. They would not be able to survive and the genes would be selected against. For example, some level of cancer will be present and is present in wild animals today as well, but when we look at mortality charts we would see that almost one in every 4 people will die from cancer. The statistic for cancer mortality shows that 23.4% of all deaths are caused by cancer. This is not directly caused by bad genes.
There is one term that scientists use that is misleading. It is a term coined as “genetic predisposition” which means something completely different. The medical industry (allopathic medicine) that is based on interventional treatments and patented drugs will openly avoid this topic.
If there is an abrupt shift in our environment there is going to be maladaptation. Even if species survive the species’ diet would not be congruent with the current environment and in time it would have to adapt to a new environment or go extinct. Because of scientific progress and technology, it is exactly this maladaptation to our current human diet and environment that have created most of our diseases. If we have an evolutionary incongruent lifestyle and eat a diet that we are not adapted to eating depending on individual genetics different diseases will emerge. Someone will die from a heart attack, someone will have an autoimmune condition and a third person will have a stroke depending on their individual genetic predisposition. But this does not mean that we have bad genes, this means that we have a bad diet. That is a term that is used in medicine as a genetic predisposition.
The only real question is what is exactly the optimal human diet that will be in line with our evolution and that will decrease the risk of chronic diseases, increase the quality of life and prolong longevity. Also, we should not forget the cost of medical treatments.
It must be a Paleo diet then, right (Fenton et al., 2016), (Pitt, 2016)?
Practitioners of this type of diet are trying to simulate the conditions of living in Stone Age hunter-gatherer conditions. They are trying to eat a diet that is in line with the pseudo-hunter-gatherer lifestyle and give up modern agricultural inventions like dairy, agrarian products, and processed foods.
This was a mystery that ended more than 70 years ago. Nutritional science is not that difficult. All we need is to look at different groups of people that have different types of diets and then look at diseases that they will have. For example, we can go to the rural places of the world that have vegan diets because of poverty and we would compare the mortality rates.
There were studies like this done long ago like a famous China study that lasted for 20 years, or Adventist Health Study (Le, 2014), or even a study of the diet on the island of Crete after WW2 that has given rise to the popular “Mediterranean diet”. People that don’t know the real Mediterranean diet have nothing to do with olive oil or red vine and it was just a vegan diet in the rural population on the island of Crete. Research showed that these people do not suffer from diseases of affluence like heart disease. “Seven Country Study” was conducted in 1956 by Ancel Keys (Menotti et al., 2015), the same scientist that did the Minnesota Starvation Experiment. People on the island of Crete didn’t eat olive oil or cheese, they were barely surviving. That is it.
Science has gone far from that initial period but still, there is resilience to accept new dietary guidelines and the food pyramid is the same. Governments to this day just ignore science. This situation has created an environment where five different people promote five different types of diets preaching their own beliefs. I compare the situation with cigarette companies in the past that used false science and paid medical doctors to promote smoking as a healthy lifestyle choice.
Research has been available for more than five decades but still, we have a situation where diet wars are waging. In reality, even if you ask a nutritional expert why is a vegan diet associated with a lower risk of heart attack, cancer, diabetes, and all other diseases of affluence most likely he would not know the real answer.
It is because of evolutional adaptations. Carnivorous species for example never develop cardiovascular disease. They are adapted completely to meat-eating and cholesterol does not pose a risk to them.
In reality, we need to take a look at the lives of our ancestors over a long time spread than just the Paleo period. It took more than 50 million years to form our bodies. Physiology is passed, from one species to another. Hominins too had inherited their anatomy from species that came before them. All life on the planet actually can be traced back to single species.
How far do we need to go? As far as we need we can understand how evolutionary adaptations form. Then we would have a complete picture of what is our real natural diet.
The first mammalian forms evolved from the cynodonts during the early Norian Age of the Late Triassic, about 225 Mya. Early mammals mostly fed on insects. They were small shrew-like animals.
The starting point of the diet was predominately insects, but they started diversifying almost immediately. It took around 140 million years for the diet to shift from insects to fruits and leaves. Not 140 thousand years, 140 million years.
In an evolutionary sense when we look at the paleo diet or something our ancestors have eaten a couple of thousands of years ago is utterly irrelevant. Physiology does change, but it needs some time to do that.
Stem primates first appear in the fossil record between 65 and 55 million years ago. They may have been the first mammals to have fingernails in place of claws.
In time, they began to spend longer periods on lower branches of trees, feeding on fruits and nuts. At the 60 Mya mark, our ancestor species had started to eat plants. In time interval to 60 Mya evolution has diversified from eating just insects and living on the ground to fruits, nuts, and insects omnivorous diet, and semi-living on trees.
Next 10 to 20 Ma is approximately the time period when diet completely shifted. Eocene Epoch (55.8-33.9 million years ago) matches the appearance of the first species of placental mammals. These orders or in other words their descendants are still present today.
Primates diverged into two suborders Strepsirrhini (wet-nosed primates) and Haplorrhini (dry-nosed primates). The Haplorrhini liver was the first one that lost the ability to make its own vitamin C. What this means is that they have been eating too many plant foods already that their bodies decided to turn off production of the vitamin C to save energy. All of their descendant species had to include fruit in the diet because vitamin C must be obtained externally. Also, this is a significant factor. Humans today too must obtain vitamin C or we will suffer and die from scurvy.
What this means is that already the early primates were dependent on plant foods on such a level that their liver discontinued producing vitamin C. In carnivores species, because they eat only meat vitamin C is produced internally, and it is not a vitamin for them. When we start to consume plants and we start to consume them in a constant manner evolution shuts down everything that is not necessary. This can tell us a lot about the diet of early primates. They transmuted to fruits and leaves instead of insects. This is the adaptation that took tens of millions of years to complete.
The point is that evolution did not begin with the emergence of modern humans in a way it stopped there because modern humans exist only three hundred thousand years. That is an insignificant number in evolutionary terms. After the great extinction of non-avian dinosaurs, the first modern forms of mammals appeared 66 million years ago. They climbed to the trees and became completely herbivorous.
There is a big difference between real omnivores that can digest rotting meat and have short intestines and plant-eating species that need to eat constantly during the entire day to get enough calories for survival. Plant eaters have a colon that ferments fiber and much longer intestines. In reality, real omnivores need to have strong resistance filters like any other carnivore or they will die from bacterial food poisoning. Humans are not true anatomical omnivores and we need to use fire and cooking in order to digest animal products. Everything can be eaten and all of the primates will eat meat if they can but this process just by itself is not natural, it is sporadic and doesn’t result in physiological adaptations.
To the time when there was a significant climate change toward the end of the Pliocene, our ancestor species lived on trees evolving on fruit and green leaves and flowers only. They have grown in size and intelligence. Most of our brain, body, genetics, evolutionary biology and physiology evolved on trees.
At the end of the Pliocene (that lasted from two million to 10,000 years ago), weather circumstances started to shift. The Pleistocene was marked by a much colder climate and recurring glaciations of the northern hemisphere. So-called Ice Age. These conditions had to force our ancestors to adapt even more perhaps to become a new type of herbivore, one entirely dependent on social and technological innovation and not just foraging. Thus, forcing adaptation that requires to a great extent increased brainpower.
Brain size thus has nothing to do with meat consumption.
Fruits, flowers, green leaves and vegetables, underground storage units, and nuts and seeds with no meat, no dairy, and no eggs were a diet that created our organism in millions of years of evolution. In hominins from the genus Homo that evolved from Australopithecines, we can see more diversification about 3.5 million years ago. At that time some members also added grasses or sedges to their menus. For another million years that was the diet.
The earliest evidence for meat-eating in hominins dates to 2.5 Mya. Some of the fossil findings are consistent with scavenging activities with no hunting. Meaning bone marrow or insects or something in similar nature in no more than a couple of percent of overall calories. Something similar to the baboons’ or chimpanzees’ diets. This meat source was insignificant to the scale of producing any physiological adaptation that will translate to any evolutionary change in biology. The adoption of large-scale meat-eating may have necessitated advanced processing techniques, such as cooking, in part because raw meat is full of putrefying bad bacteria and other types of bad micro-organisms and parasites that will eventually kill us if are not killed by a thermal process. Thus limiting consumption in large quantities.
The limiting factor that a large number of scientists do not seem to understand is that meat spoils very quickly in the hot savanna conditions of Africa. In 2h, just two, it is gone. In 15 minutes there would already be insects crawling on top of the carcass and also there would be other predators looking for an easy meal.
In order to consume meat on a scale that will be significant to create an adaptation, it will have to be the staple of the diet with a calorie influx of at least 10 to 15 percent. That will be a real omnivorous diet. Without large-scale hunting on a daily basis, that is impossible. Without technology, like traps or spears, it is not a logical assumption and without cooking, it is 100%, not a viable option.
The first time in the evolution of the entire human species where meat consumption would be a reliable and sustainable source of calories would be in already modern humans that use technology. Even in the Paleo period, the real archeological evidence shows that meat was not a sustainable source of diet and that it was more in line with being an added benefit to foraging. Foraging was first and hunting second. The real Paleo diet is something completely different than what people would like to think.
An omnivorous diet is a wide range of diets. It might be 99% fruits and 1% of insects. True omnivores like bears can feed on carcasses. Our natural human diet is something that our hominin ancestors were eating, not anatomically modern humans in the Stone age. In reality, we can get away with some meat consumption without a dramatic increase in our chronic disease risk and science now has all of the answers (Sinha et al., 2009).
The problem is with us, people because we want our food to be a source of gratification and that is not food that exists in nature. Refined calories and animal products are not congruent with our biology and as a consequence, we will have to deal with an increase in disease risk. The first step in the prevention of chronic diseases is the lowering consumption of animal products and refined food.
If you have any dilemma about what is our natural human diet just go to nature. It is a human diet that we would be able to have without using technology like spears, traps, bows, and arrows.
References:
- Fenton, T. R., & Fenton, C. J. (2016). Paleo diet still lacks evidence. The American journal of clinical nutrition, 104(3), 844. https://doi.org/10.3945/ajcn.116.139006
- Pitt C. E. (2016). Cutting through the Paleo hype: The evidence for the Palaeolithic diet. Australian family physician, 45(1), 35–38. [PubMed]
- Le, L. T., & Sabaté, J. (2014). Beyond meatless, the health effects of vegan diets: findings from the Adventist cohorts. Nutrients, 6(6), 2131–2147. https://doi.org/10.3390/nu6062131
- Menotti, A., & Puddu, P. E. (2015). How the Seven Countries Study contributed to the definition and development of the Mediterranean diet concept: a 50-year journey. Nutrition, metabolism, and cardiovascular diseases : NMCD, 25(3), 245–252. https://doi.org/10.1016/j.numecd.2014.12.001
- Sinha, R., Cross, A. J., Graubard, B. I., Leitzmann, M. F., & Schatzkin, A. (2009). Meat intake and mortality: a prospective study of over half a million people. Archives of internal medicine, 169(6), 562–571. https://doi.org/10.1001/archinternmed.2009.6
Related Posts
Do you have any questions about nutrition and health?
I would love to hear from you and answer them in my next post. I appreciate your input and opinion and I look forward to hearing from you soon. I also invite you to follow us on Facebook, Instagram, and Pinterest for more diet, nutrition, and health content. You can leave a comment there and connect with other health enthusiasts, share your tips and experiences, and get support and encouragement from our team and community.
I hope that this post was informative and enjoyable for you and that you are prepared to apply the insights you learned. If you found this post helpful, please share it with your friends and family who might also benefit from it. You never know who might need some guidance and support on their health journey.
– You Might Also Like –

Learn About Nutrition
Milos Pokimica is a doctor of natural medicine, clinical nutritionist, medical health and nutrition writer, and nutritional science advisor. Author of the book series Go Vegan? Review of Science, he also operates the natural health website GoVeganWay.com
Medical Disclaimer
GoVeganWay.com brings you reviews of the latest nutrition and health-related research. The information provided represents the personal opinion of the author and is not intended nor implied to be a substitute for professional medical advice, diagnosis, or treatment. The information provided is for informational purposes only and is not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider.NEVER DISREGARD PROFESSIONAL MEDICAL ADVICE OR DELAY SEEKING MEDICAL TREATMENT BECAUSE OF SOMETHING YOU HAVE READ ON OR ACCESSED THROUGH GoVeganWay.com
NEVER APPLY ANY LIFESTYLE CHANGES OR ANY CHANGES AT ALL AS A CONSEQUENCE OF SOMETHING YOU HAVE READ IN GoVeganWay.com BEFORE CONSULTING LICENCED MEDICAL PRACTITIONER.
In the event of a medical emergency, call a doctor or 911 immediately. GoVeganWay.com does not recommend or endorse any specific groups, organizations, tests, physicians, products, procedures, opinions, or other information that may be mentioned inside.
Editor Picks –
Milos Pokimica is a health and nutrition writer and nutritional science advisor. Author of the book series Go Vegan? Review of Science, he also operates the natural health website GoVeganWay.com
Latest Articles –
Top Health News — ScienceDaily
- Women over 50 lost 35% more weight with this surprising comboon March 24, 2026
Postmenopausal women may have a powerful new edge in the battle against weight gain. A Mayo Clinic study found that those using menopausal hormone therapy while taking the obesity drug tirzepatide lost about 35% more weight than those on the drug alone. The findings hint at a surprising synergy between hormones and cutting-edge weight-loss medications, potentially opening the door to more effective, personalized treatments for millions of women facing increased cardiometabolic risks after […]
- This new tooth powder whitens teeth without damageon March 24, 2026
Researchers have developed a teeth-whitening powder that works with the vibrations of an electric toothbrush to safely remove stains. Unlike traditional whiteners, it not only brightens teeth but also repairs enamel and supports healthy oral bacteria. Lab tests showed dramatic whitening effects, while animal studies revealed reduced harmful microbes and inflammation. This could pave the way for a new generation of at-home dental care.
- Scientists discover Alzheimer’s hidden “death switch” in the brainon March 23, 2026
Scientists have uncovered a hidden “death switch” in the brain that may be driving Alzheimer’s disease—and even found a way to turn it off in mice. The culprit is a toxic pairing of two proteins that, when combined, triggers the destruction of brain cells and fuels memory loss. By using a new compound to break apart this deadly duo, researchers were able to slow disease progression, protect brain cells, and even reduce hallmark amyloid buildup.
- New blood test could catch pancreatic cancer before it’s too lateon March 23, 2026
A new blood test could change the outlook for one of the deadliest cancers—pancreatic cancer—by catching it much earlier than ever before. Researchers identified two previously unknown proteins in the blood that, when combined with existing markers, dramatically improved detection accuracy. The four-marker test was able to spot pancreatic cancer in over 90% of cases and performed especially well even in early stages, when treatment has the best chance of success.
- A promising fatty liver treatment may raise cancer riskon March 23, 2026
A surprising new study reveals that blocking a supposedly protective enzyme, Caspase-2, could actually backfire—raising the risk of chronic liver damage and cancer over time. Researchers found that without this enzyme, liver cells grow abnormally large and accumulate genetic damage, leading to inflammation, scarring, and eventually tumors, especially with age. While inhibiting Caspase-2 may offer short-term benefits, such as reducing fatty liver disease, the long-term consequences appear […]
- Scientists discover surprising brain trigger behind high blood pressureon March 23, 2026
Scientists have uncovered a surprising brain-based trigger for high blood pressure, tracing it to a small region in the brainstem that normally controls breathing. This area, which kicks in during forceful exhalations like coughing, laughing, or exercise, also appears to activate nerves that tighten blood vessels—raising blood pressure. When researchers switched off this region in experiments, blood pressure dropped back to normal, suggesting it plays a direct role in hypertension.
- Weight loss drug Ozempic cuts depression, anxiety, and addiction riskon March 22, 2026
GLP-1 medications like semaglutide (Ozempic) may offer unexpected mental health benefits alongside weight loss. A large study found major drops in depression, anxiety, and psychiatric-related hospital visits among users. Even substance use disorders were significantly lower during treatment. Researchers suspect both lifestyle improvements and direct brain effects could be at play.
PubMed, #vegan-diet –
- Plant-Based Dietary Patterns and Neuroimaging Biomarkers of Brain Health: A Scoping Review of Observational and Interventional Evidenceon March 23, 2026
Healthy dietary interventions are well established in cardiovascular disease prevention, but their effects on the brain remain underexplored. This scoping review aims to investigate how adherence to core components of a whole-food plant-based diet (WFPBD) may impact neuroimaging outcomes across different brain conditions. We searched PubMed and MEDLINE for studies published in the past 20 years evaluating the effects of a predominantly or exclusively WFPBD, alone or combined with other […]
- Environmental and economic impact of a vegan versus traditional mediterranean diet: OMNIVEG studyon March 17, 2026
CONCLUSIONS: Replacing animal products with plant-based foods in a Mediterranean dietary framework can enhance environmental sustainability and reduce food costs. These findings support the promotion of whole plant-based diets as a viable strategy for sustainable and affordable nutrition.
- Consumption Habits and Perception of Plant-Based Milk and Dairy Alternatives Among Vegetarians and Omnivores: A Case Study of Consumers in Sloveniaon March 14, 2026
CONCLUSIONS: PBMDA perceptions in Slovenia are strongly segmented by dietary pattern and socio-demographics, supporting the need for clearer nutrition communication.
- Culinary Nutrition Programming for Members of a Community-Based Cancer Programon March 14, 2026
(1) Background: Nutrition research in cancer care has largely focused on disease prevention and management, overlooking the importance of food literacy. Culinary cancer care programs may address this gap by facilitating the practical application of nutrition through culinary skills, fostering social connections over nutrient-dense meals, and supporting individuals during periods of physical and social vulnerability. The Not-Just-Supper Club (NJSC) at Gilda’s Club Toronto (GT) is a…
- Fatty acid composition of ground-beef products and their plant-based meat substitutes available in Hungaryon March 13, 2026
CONCLUSION: The findings indicate that plant-based meat alternatives (except those containing coconut oil) have lower saturated and higher polyunsaturated fatty acid compositions than beef-based products, leading to more beneficial nutritional value. Further analytical and clinical studies are necessary to provide a more comprehensive understanding of the long-term health effects of these foods.
Random Posts –
Featured Posts –
Latest from PubMed, #plant-based diet –
- From cow to crop: motives and barriers for plant-based dairy alternative consumption across three European countriesby Dominika Maison on March 23, 2026
Currently, alternative sources of protein are being sought to replace not only meat but also dairy products in the diet. From this perspective, it is worth examining how consumers perceive these products, what motivates them to choose them and what barriers they encounter, especially with regard to attitudes towards dairy products. The present study aimed to compare attitudes towards plant-based dairy alternatives (PBDAs) in three European countries – Poland, Germany and the UK. Furthermore, […]
- Energy and macronutrient intakes of Montenegrin adults: insights from the EFSA EU Menu National Survey (2017-2022)by Amil Orahovac on March 23, 2026
INTRODUCTION: Understanding population-level dietary intakes is essential for preventing diet-related non-communicable diseases (NCDs) and informing evidence-based nutrition policies. Until recently, Montenegro lacked nationally representative data on food and nutrient intake aligned with European Food Safety Authority (EFSA) standards. This study provides the first comprehensive analysis of energy and macronutrient intake among Montenegrin adults within the EFSA EU Menu framework.
- Plant-Based Dietary Patterns and Neuroimaging Biomarkers of Brain Health: A Scoping Review of Observational and Interventional Evidenceby Lydia Viviana Falsitta on March 23, 2026
Healthy dietary interventions are well established in cardiovascular disease prevention, but their effects on the brain remain underexplored. This scoping review aims to investigate how adherence to core components of a whole-food plant-based diet (WFPBD) may impact neuroimaging outcomes across different brain conditions. We searched PubMed and MEDLINE for studies published in the past 20 years evaluating the effects of a predominantly or exclusively WFPBD, alone or combined with other […]
- Performance of Amblyseius swirskii (Acari: Phytoseiidae) on different astigmatid prey: life history traits and multi-generational stabilityby Marziye Jahanbazi on March 22, 2026
Optimizing trophic interactions within factitious prey chains is critical for the sustainable mass production of biological control agents. We investigated the developmental and demographic performance of Amblyseius swirskii (Athias-Henriot) (Acari: Phytoseiidae) when fed on four storage mite species, Tyrophagus putrescentiae (Schrank) (Acari: Acaridae), Carpoglyphus lactis L. (Acari: Carpoglyphidae), Lepidoglyphus destructor (Schrank) (Acari: Glycyphagidae), Rhizoglyphus robini Claparede…
- Association Between Healthy Eating Patterns and Prevalence of Suspected Polycystic Ovary Syndrome: A Cross Sectional Studyby Lingling Huang on March 20, 2026
The diet-PCOS relationship remains complex and requires further investigation. Among 1424 participants (12.3% suspected PCOS), dietary patterns were evaluated using NIH criteria via FFQ: exploratory factor analysis (EFA), EAT-Lancet dietary pattern (EAT-LDP), Mediterranean, plant-based indices. EFA identified four patterns: plant-forward (PFD), animal-protein (APD), red and organ meat (ROM), and fast-food (FFD). Multivariable logistic regression, adjusted for age, BMI, education attainment,…
- A systematic evaluation of online guidance for managing hyperkalemia through dietary approaches in individuals with chronic kidney diseaseby Masuda Akter on March 20, 2026
CONCLUSION: Dietary guidance online for managing hyperkalemia risk did not reflect recent shifts in the literature, and primarily consisted of complicated food lists that lacked consistency. Research is needed to standardize, and evaluate the efficacy of the food list based approach to practice.









































