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by Milos Pokimica ND

by Milos Pokimica ND

Learn About Nutrition

Longevity- The rate of living theory

"The higher the metabolism, the higher the oxidative damage, and the higher the cell division. Every time cell divide it clips telomere in half and our longevity"

What happens when our regular metabolism burns energy for life? Well, some of that energy escapes and does damage to DNA decreasing our longevity. Some of the damaged cells naturally end their life cycle and die. In their place comes new ones from the division.

The higher the metabolism, the higher the damage, and the higher the division. Every time a cell divide it clips the telomere in half. A telomere is a small area of repeated nucleotide sequences at each end of a chromosome.

telomee
Telomere Shortening

The purpose of the telomere is to keep the end of the chromosome from deterioration or fusion with other neighboring chromosomes. During chromosome duplication, the enzymes that duplicate DNA can maintain their duplication unit at the end of a chromosome. What happens is that in each duplication, the end of the chromosome is shortened. After too many divisions telomeres are gone, and there are no more divisions only death. It is a process called aging.

We can slow this process down and increase our longevity by slowing oxidative damage with high levels of antioxidants in the diet, and we can slow it down by increasing energy efficiency. The problem is that nothing in nature is 100% effective. Some of the oxygen in our cells escapes in the form of free radicals and do their oxidation elsewhere.

free-radicals
Free Radicals Metabolism

Oxidative stress happens when an oxygen molecule splits into single atoms with unpaired electrons. These aggressive molecules are called free radicals. They are so aggressive that they will attack the nearest stable molecule trying to steal its electron particle. When the attacked particle is left with no electron, it will become the free radical itself. The process is going to create a chain reaction. Once the process is started, the final result is the disruption of a living cell.

Free radicals are created as a part of normal metabolism.

free-radical-formation
Free Radical Formation

Four different mechanisms produce endogenous (your body creates them) free radicals. Production of free radicals cannot be entirely stopped. It is surprisingly amusing to me that oxygen, an element indispensable for life is also responsible for our death.

It is not plausible to directly measure the number of free radicals in the body. The more fuel we burn, the faster we burn out.

Have you ever asked yourself how many heartbeats a common man has in their life? It turns out each animal gets around a billion beats. Smaller animals have higher metabolic rates, and their heart is beating faster. When we calculate the number of beats for different sizes of different species of animals the magic number is one billion. Horses, rabbits, cats, pigs, elephants, whales, it does not matter, it is always one billion. Other than small dogs. They got the short end of the stick. In contrast, humans and chickens are champions in that we get more than double the usual natural number. Around 2.21 billion for us and 2.17 billion beats for chickens. The quicker your metabolism is the faster you will oxidase and the shorter is your longevity.

It is called the rate of living theory. Max Rubner had first proposed the concept in 1908. He observed that larger animals always outlived smaller ones and that the larger animals had slower metabolisms. A further affirmation was given to these observations by the discovery of Max Kleiber’s law in 1932. Kleiber assumed that basal metabolic rate could correctly be predicted by taking 3/4 the power of body weight.

This theory is colloquially known as the mouse-to-elephant curve. Support for this theory has been reinforced by studies linking a lower basal metabolic rate (evident with a lowered heartbeat) to increased life expectancy. Grand Tortoise can live up to 150 years. Hummingbirds have the highest metabolism of any homoeothermic animal. Their hearts beat at over 1263 beats per minute. At night, they enter tupor, a form of deep sleep. In tupor their heart rate drops to 50 beats a minute to conserve energy. The average lifespan of a wild hummingbird is 3-10 years.

mouse to elephant curve
Mouse to elephant curve

One species that stick out for longevity are Macaws. Birds in general average some 2 to 3 times the longevity of mammals. There are specific avian groups that are even longer-lived than this overall average. Why and how nobody knows. The interesting fact is that oxygen consumption in a unit of time in bird cells can go as high as 2.5 times that of mammals. If we combine this fact of high metabolic rate and oxygen consumption with the long lives of birds, we have unsolved scientific phenomena. If we calculate the numbers, we can see that some long-lived avian cells may be able to live as much as 20 times longer than some of the short-lived mammals such as mice and five times that of regular long-lived mammals such as humans. If we find out how and what the secret is, we could possibly have five times of life expectancy. Birds have evolved some protection against free radical damage. They have evolved some effective mechanisms for protection from the buildup of free radicals. The circumstances of those protective measures so far remain elusive. Longevity is a big topic in today’s scientific research.

Studies within those sectors of oxidative free radical protection have so far been restricted, and the evidence has been moderately conflicting. It will be significant in pharmaceutics, it already is. Universal strong antioxidant and calorie restriction pill, all we can eat and still have the benefits. There are multiple substances that undergo experiments within the pharmaceutical industry, for example, one substance is called Compound SRT1720. SRT1720 mimics dietary restriction, lessening many of the harmful effects of the high-fat diet and obesity with no signs of toxicity even after 80 weeks of treatment. We cannot buy this stuff yet.

What we can do is a dietary intervention in order to optimize our antioxidant intake. What we can have at present is something in the form of strong universal antioxidants like Astaxanthin, Curcumin, or MegaHydrate and increase our dietary intake of antioxidants from food. There is extensive research that is already available and optimizing our ORAC dietary intake levels is recommended to anyone especially in people that have some sort of inflammation and as a prevention from chronic diseases like cancer, aging, diabetes, cardiovascular disease, liver and kidney problems, neurodegenerative disorders (3).

There is no more debate on the list in the scientific field anymore about antioxidant intake. More research had to be done, especially to see if the high rate of dietary antioxidants had an adverse effect on immune cells that use the release of oxygen free radicals like macrophages. There is also evidence that antioxidants like beta-carotene can harm us if not taken in a whole food way. In the future, there will probably be much more research done in this area.

Big Bristlecone pine Pinus longaeva- Longest living specieson earth
Big Bristlecone pine Pinus longaeva- Species with the highest longevity on Earth

In one study that I will mention (4) they analyzed one type of bristlecone pines, Pinus longaeva. It is the oldest known living eukaryotic organism, with the oldest on record turning 4780 years old in 2015. In this study, researchers did a detailed investigation of telomere length and telomerase activity. Telomerase is a ribonucleoprotein an enzyme that adds a species-dependent telomere repeat sequence to the end of telomeres. It lengthens the telomeres. Some cells, not all of them can maintain telomere length by the action of this enzyme, thus keeping themselves from death. The conclusions of the research confirm the assumption that:

“Both increased telomere length and telomerase activity may directly/indirectly contribute to the increased life-span and longevity evident in long-lived pine trees (2000-5000 year life-spans).”

In the future, we will have some t-pill maybe, but until that time we need to correct our lifestyle. Periodical fasting can be one way. It will help us as much as exercise and as much as a good diet.

However, who will actually do this? Ascetic monks. On a population scale, it is not sustainable, and actually, on a population scale, we see reverse action. For us, it is all about how to overcome our metabolism and calorie adaptation so that we can eat more, lose weight more quickly, and have six-pack abs and French fries at the same time. Many people describe dieting to be a 50% physiological battle and a 50% psychological battle, and they are not far off from the mark unless you can deal with the intensive food cravings you face. Most people on a diet are running a calorie deficit of around 500 calories below maintenance. After metabolic adaptation takes place, we can see how fast weight loss would go. Moreover, just around the corner are birthday parties, holidays, and of course, cheat meals. Eating for pleasure is nothing new.

Related Posts

  1. ouroboros
  2. do not eat fish sign
  3. iStock 926182488

Sources:

Passages selected from a book: “Go Vegan? Review of Science: Part 1” [Milos Pokimica]

  1. The Rate of Living Theory Revisited doi: 10.1159/000212998
  2. Testing the Rate-of-Living/Oxidative Damage Theory of Aging in the Nematode Model Caenorhabditis Elegans doi: 10.1016/j.exger.2007.02.004
  3. Medicinal Prospects of Antioxidants: A Review doi: 10.1016/j.ejmech.2019.06.010.
  4. Analysis of telomere length and telomerase activity in tree species of various lifespans, and with age in the bristlecone pine Pinus longaeva; Biogerontology. 2005;6(2):101-11

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Know Public Health has no rights of this documentary, we just have shared the video for public health interest. All rights go to, Producers and Directors and the media house for this movie.
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Are we omnivores, carnivores or herbivores? It’s important for animals to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat? Dr. Sofia Pineda Ochoa discusses this often misunderstood topic.

The first part of the transcript is included below for reference, and the full transcript (which is too long to have here) is available on our website, along with sources and credits, at this link: http://meatyourfuture.com/2015/09/herbivores-carnivores/

[The following transcript is an approximation of the audio in  video. To hear the audio and see the accompanying visuals, please play the video.]

PARTIAL TRANSCRIPT:

Are humans herbivores, carnivores or omnivores? It’s very important for a given animal to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat?

When looking at a species to determine what they are in terms of carnivore, omnivore or herbivore, we can look at their behavior or we can look at their biology. From a behavioral standpoint, humans behave as omnivores because we observe many humans in their behavior eating a wide variety of both animal and plant-based foods. Biologically, however, from a physiologic and anatomic standpoint, it’s a different story.

Dr. Williams C. Roberts from the National Institutes of Health and Baylor University — who is the editor-in-chief of the American Journal of Cardiology and one of the most prominent cardiologists in the world with over 1,500 publications in peer reviewed medical journals — summarized our answer very nicely. He wrote:

“Although most of us conduct our lives as omnivores, in that we eat flesh as well as vegetables and fruits, human beings have characteristics of herbivores, not carnivores. The appendages of carnivores are claws; those of herbivores are hands or hooves. The teeth of carnivores are sharp; those of herbivores are mainly flat (for grinding). The intestinal tract of carnivores is short (3 times body length); that of herbivores, long (12 times body length). Body cooling of carnivores is done by panting; herbivores, by sweating. Carnivores drink fluids by lapping; herbivores, by sipping. Carnivores produce their own vitamin C, whereas herbivores obtain it from their diet. Thus, humans have characteristics of herbivores, not carnivores.”

That’s right. Humans have characteristics of herbivores, not carnivores or omnivores — because omnivores, like bears and raccoons, actually retain most of the carnivorous characteristics, so that they are still able to digest and hunt their prey, and do so effectively.

[Remainder of transcript, along with sources and credits, available here: http://meatyourfuture.com/2015/09/herbivores-carnivores]

Are we omnivores, carnivores or herbivores? It’s important for animals to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat? Dr. Sofia Pineda Ochoa discusses this often misunderstood topic.

The first part of the transcript is included below for reference, and the full transcript (which is too long to have here) is available on our website, along with sources and credits, at this link: http://meatyourfuture.com/2015/09/herbivores-carnivores/

[The following transcript is an approximation of the audio in video. To hear the audio and see the accompanying visuals, please play the video.]

PARTIAL TRANSCRIPT:

Are humans herbivores, carnivores or omnivores? It’s very important for a given animal to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat?

When looking at a species to determine what they are in terms of carnivore, omnivore or herbivore, we can look at their behavior or we can look at their biology. From a behavioral standpoint, humans behave as omnivores because we observe many humans in their behavior eating a wide variety of both animal and plant-based foods. Biologically, however, from a physiologic and anatomic standpoint, it’s a different story.

Dr. Williams C. Roberts from the National Institutes of Health and Baylor University — who is the editor-in-chief of the American Journal of Cardiology and one of the most prominent cardiologists in the world with over 1,500 publications in peer reviewed medical journals — summarized our answer very nicely. He wrote:

“Although most of us conduct our lives as omnivores, in that we eat flesh as well as vegetables and fruits, human beings have characteristics of herbivores, not carnivores. The appendages of carnivores are claws; those of herbivores are hands or hooves. The teeth of carnivores are sharp; those of herbivores are mainly flat (for grinding). The intestinal tract of carnivores is short (3 times body length); that of herbivores, long (12 times body length). Body cooling of carnivores is done by panting; herbivores, by sweating. Carnivores drink fluids by lapping; herbivores, by sipping. Carnivores produce their own vitamin C, whereas herbivores obtain it from their diet. Thus, humans have characteristics of herbivores, not carnivores.”

That’s right. Humans have characteristics of herbivores, not carnivores or omnivores — because omnivores, like bears and raccoons, actually retain most of the carnivorous characteristics, so that they are still able to digest and hunt their prey, and do so effectively.

[Remainder of transcript, along with sources and credits, available here: http://meatyourfuture.com/2015/09/herbivores-carnivores]

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YouTube Video UExXSlpBTjg5dURrWGF0Wkl0aDlDZG55UE1ZcEZ5dUlrbC5DRUQwODMxQzUyRTlGRkY3

Are humans omnivores, carnivores or herbivores?

GoVeganWay 351K views September 4, 2021 12:32 am

How much is a human life worth? An innovative cancer therapy promises to save lives. But it is extremely expensive. Will the insurance companies pay for it? What is the manufacturer's return on investment? And do lobbyists drive up prices?

In 2018, the Kymriah gene therapy was approved in Europe. Immune cells are taken from the patient, genetically reprogrammed into cancer killer cells and returned to the patient as an infusion. The results of the Kymriah study only cover a period of 18 months. In 40 percent of patients, lymph gland cancer does not return during this time. It is not clear whether Kymriah has a long-term effect. The Swiss pharmaceutical company Novartis offers the new therapy - it costs 370,000 Swiss francs per patient. Health insurance companies are not usually prepared to pay that much and are complaining about a lack of transparency. 

But the killer cells were not invented in the Novartis laboratories, but at a US university. When Professor Carl June started his research almost 30 years ago, no pharmaceutical company was interested. It was only thanks to funding from tax money and donations that he was able to develop Kymriah at all. After a story went around the world about a girl with leukemia whose cancer disappeared thanks to Kymriah, the pharmaceutical company contacted Novartis and secured exclusive marketing rights. To launch Kymriah on the market, Novartis funded the necessary clinical trials. It's not an isolated incident: Over 60% of newly approved medicines in the US are developed by small biotech companies or universities. Pharmaceutical companies today frequently act as capital providers, cooperating with universities or buying up biotech companies. 

A paradigm shift has taken place in the pharmaceutical industry: Whereas high drug prices used to be justified by research costs, the industry is now using the value of gained lifetime to argue its case. 

 -------------------------------------------------------------------

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How much is a human life worth? An innovative cancer therapy promises to save lives. But it is extremely expensive. Will the insurance companies pay for it? What is the manufacturer's return on investment? And do lobbyists drive up prices?

In 2018, the Kymriah gene therapy was approved in Europe. Immune cells are taken from the patient, genetically reprogrammed into cancer killer cells and returned to the patient as an infusion. The results of the Kymriah study only cover a period of 18 months. In 40 percent of patients, lymph gland cancer does not return during this time. It is not clear whether Kymriah has a long-term effect. The Swiss pharmaceutical company Novartis offers the new therapy - it costs 370,000 Swiss francs per patient. Health insurance companies are not usually prepared to pay that much and are complaining about a lack of transparency.

But the killer cells were not invented in the Novartis laboratories, but at a US university. When Professor Carl June started his research almost 30 years ago, no pharmaceutical company was interested. It was only thanks to funding from tax money and donations that he was able to develop Kymriah at all. After a story went around the world about a girl with leukemia whose cancer disappeared thanks to Kymriah, the pharmaceutical company contacted Novartis and secured exclusive marketing rights. To launch Kymriah on the market, Novartis funded the necessary clinical trials. It's not an isolated incident: Over 60% of newly approved medicines in the US are developed by small biotech companies or universities. Pharmaceutical companies today frequently act as capital providers, cooperating with universities or buying up biotech companies.

A paradigm shift has taken place in the pharmaceutical industry: Whereas high drug prices used to be justified by research costs, the industry is now using the value of gained lifetime to argue its case.

-------------------------------------------------------------------

DW Documentary gives you knowledge beyond the headlines. Watch high-class documentaries from German broadcasters and international production companies. Meet intriguing people, travel to distant lands, get a look behind the complexities of daily life and build a deeper understanding of current affairs and global events. Subscribe and explore the world around you with DW Documentary.

Subscribe to:
DW Documentary: https://www.youtube.com/channel/UCW39zufHfsuGgpLviKh297Q?sub_confirmation=1#

DW Documental (Spanish): https://www.youtube.com/dwdocumental
DW Documentary وثائقية دي دبليو: (Arabic): https://www.youtube.com/dwdocarabia

For more visit:
http://www.dw.com/en/tv/docfilm/s-3610
Instagram:
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Facebook:
https://www.facebook.com/dw.stories

DW netiquette policy: https://p.dw.com/p/MF1G

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The power of the pharmaceutical companies | DW Documentary

GoVeganWay 648.6K views September 4, 2021 12:24 am

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