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by Milos Pokimica ND

by Milos Pokimica ND

Learn About Nutrition

Alcohol health risks- The “French paradox”, “the wine”, and “in moderation”

"Somehow we believe that one glass of wine is not all that bad, or even worse, we believe in alcohol health-promoting myth because of the grape's antioxidants."

We all know that alcohol is a bad and toxic substance for us and that alcohol health risks are real. But somehow we all believe that one glass of wine is not all that bad and actually is good and somehow health-promoting because of all of its antioxidants from the grapes. A pregnant woman will avoid drinking alcohol because of fetal development but usually, people are just not aware that alcohol does much more than killing our brain cells. It is a genotoxic, cancerous, pro-inflammatory mutagen.

Possible_long-term_effects_of_ethanol

The developing fetus and adolescent brain are primarily vulnerable to the toxic effects of alcohol and this is the reason why it is absolutely forbidden in pregnancy. If the mother drinks during pregnancy that will have an adverse effect on fetal development. The most severe condition in this spectrum of diseases is known as fetal alcohol syndrome (FAS).

dysmorphic-features-of-fetal-alcohol-syndrome-n

Alcohol is something as known as a teratogen, and that means that it prevents the cells from developing by blocking maternal and fetal enzymes.

“Alcohol can act as a teratogen through numerous methods including reactive oxygen species (generated as byproducts of CYP2E1), decreased endogenous antioxidant levels, mitochondrial damage, lipid peroxidation, disrupted neuronal cell-cell adhesion, placental vasoconstriction, and inhibition of cofactors required for fetal growth and development.” (1) This is well understood and it does not need any further clarification.

In healthy adults, alcohol restricts to some extent the production of vasopressin (ADH). (3) It is a hormone produced in the hypothalamus and is secreted from the posterior pituitary gland. Dehydration after alcohol consumption is a consequence of this restriction. This might be a reason for the hangover to a smaller extent. Hangover just by itself is not dehydration. You might try to prevent a hangover the morning after by consuming large amounts of fluid during binge drinking but that would not completely prevent restriction of vasopressin and dehydration. “Also, markers of dehydration (e.g., vasopressin) were not significantly related to hangover severity. Analyses showed that concentrations of various hormones, electrolytes, free fatty acids, triglycerides, lactate, ketone bodies, cortisol, and glucose were not significantly correlated with reported alcohol hangover severity. Some studies report a significant correlation between blood acetaldehyde concentration and hangover severity, but most convincing is the significant relationship between immune factors and hangover severity. The latter is supported by studies showing that hangover severity may be reduced by inhibitors of prostaglandin synthesis. Several factors do not cause alcohol hangovers but can aggravate their severity. These include sleep deprivation, smoking, congeners, health status, genetics, and individual differences.” (4)

People who regularly drink more than one standard drink per day are at higher risk of long-term health conditions. Even if you do not feel the effect of the drink, you did yourself harm. And that is not all. Alcohol consumption releases excess GABA and dopamine. If too much of these neurotransmitters get released situation can change dramatically from feeling nice and relaxed to increased heart rate, shortness of breath, increased levels of both aggression and depression, high blood pressure, delusions, hallucinations, night terrors, spasms, and so on. (5)

Excess drinking causes the liver to accumulate fat, which can lead to fatty liver disease especially if you are already obese.

“Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide. ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is characterized by hepatic inflammation. Chronic ASH can eventually lead to fibrosis and cirrhosis and in some cases hepatocellular cancer (HCC). In addition, severe ASH (with or without cirrhosis) can lead to alcoholic hepatitis, which is an acute clinical presentation of ALD that is associated with liver failure and high mortality. Most individuals consuming >40 g of alcohol per day develop AFL; however, only a subset of individuals will develop more advanced disease.” (6)

All of these alcohol health risks are well known but what is not so known is that even just one drink a day may increase the person’s risk for breast cancer by 4% because alcohol has a pro-estrogenic influence on the cells. Cancers that are responsive to hormones will also have a positive response to substances that influence hormones like for instance breast cancer. The increase in the order of 4% is done just by one small alcoholic drink/day. (7)

If you drink three or more drinks a day, then your breast cancer risk goes up by, imagine this 40-50 percent.

alcohol cancer

Around 5 percent of all breast cancers in the US are attributed just to alcohol consumption and around 1 to 2 percent to light drink alone. Combine this with the pro-estrogenic effects of POPs and plastic and all other xenoestrogens.

Besides breast cancer, 3.6% of other types of cancers are caused directly by chronic alcohol drinking, and these include the liver, the colorectum, and those of the upper digestive tract ones. (8)

The International Agency for Research on Cancer (IARC) official UN body under the WHO considers ethanol as a carcinogen to humans (Group 1). Besides ethanol alcoholic beverages are multicomponent mixtures that can be containing several different carcinogenic compounds, such as acetaldehyde, aflatoxins, and ethyl carbamate. Ethanol is considered the most important carcinogen in alcoholic beverages, but there are other carcinogenic compounds as well.

The biological mechanisms by which alcohol intake increases the risk of cancer are not fully understood, but the primary mechanisms are likely to include a genotoxic effect of acetaldehyde, the induction of cytochrome P450 2E1 and associated oxidative stress, increased estrogen concentration, a role as a solvent for tobacco carcinogens, changes in folate metabolism, and changes in DNA repair.

For cancers of the digestive tract, especially those of the upper digestive tract, acetaldehyde (derivate from alcohol that creates itself almost instantly when you sip on an alcoholic beverage) has been highlighted as a likely and important causal pathway. That metabolite is so toxic it is terrible.

For colorectal cancer, in addition to the genotoxic effect of acetaldehyde, there may be the involvement of folate: alcohol may act through folate metabolism or synergistically with low folate intake. Bacteria in our mouths oxidase ethanol into acetaldehyde almost instantaneously. Even a single sip is enough to cause high concentrations of acetaldehyde even without drinking, there is still an effect for example if you use alcoholic mouthwash. In this study (9) they found that holding a single sip of a strong alcoholic beverage for 5 seconds in the mouth and then spitting it out formed carcinogenic concentrations of acetaldehyde in the oral cavity instantly and the exposure continued for at least 10 min. So even washing your mouth with it is cancer-promoting.

There is also more to booze than just cancer. Alcohol rises lipids in the blood and also blood pressure. That will increase the risk of raised cholesterol, hypertension, stroke, and heart attack. It causes cardiomyopathy, myocarditis and it also causes arrhythmia.

However, wait red wine has long been considered the elixir of heart health. We can all remember the scam named French paradox.

60minutes
You can watch the video here.

French paradox was a love affair for everyone. In 1980 some French scientists tried to explain the correlation between high fat intake, and especially saturated one from lots of meat and dairy products with lower heart attack rates in France especially when compared with one in Britain for example. It was statistical proof that cholesterol and all of meat and eggs and cheese do not cause heart disease and even if they do we can just add some nice red wine after the meal and what more do you want. Red wine is some kind of superfood. However, correlation is not causation, and one factor that had been ignored was, and I will write it again was, the past tense, that the French diet was generally healthier than other nations at the time. They had been eating four times more vegetables than counterpart countries and it was a form of a semi Mediterranean diet. However, it turned out to be no paradox at all. It turned out that French physicians underreport heart disease on death certificates as much as 20% according to WHO. If we correct that statistical error, then no benefit of wine. The only good thing in wine is phytochemicals from grapes so if you want these, the better option will be just regular grape juice and the even better option will be to eat fresh grapes.

Some other studies support alcohol health risks correlation with heart disease connection. Low levels of alcohol consumption can raise levels of high-density lipoprotein (good cholesterol), HDL. So they had the idea that moderate drinking protects against cardiovascular disease by raising HDL, which would make sense biologically if you already have razed levels of cholesterol. They need this kind of study to calm people down from time to time. Alternatively, we will stop eating animal products if we fear cholesterol. Also, some small amount of alcohol consumption like a glass of wine a day had been found to have beneficial changes in factors that influence blood clotting, and that will mean fewer chances for thrombosis of any sort like blood clots in the brain, block arteries in the heart and so on. Blood clots are the most common kind of stroke. Booze is what chemists call amphiphilic. It interacts favorably with both polar and non-polar molecules same as any other amphiphilic substance like soaps and detergents. So if you add rubbing alcohol to grease, the alcohol starts mixing with it. It blends in by going in between the long fatty chains. It does the same thing in the bloodstream. 

Alternatively, you can take aspirin; it has a similar effect to blood clots without liver damage and cancer.

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Sources:

Passages selected from a book: “Go Vegan? Review of Science: Part 1” [Milos Pokimica]

  1. An Update on Fetal Alcohol Syndrome-Pathogenesis, Risks, and Treatment DOI: 10.1111/acer.13135
  2. Impact of Fetal Alcohol Exposure on Body Systems: A Systematic Review doi: 10.1002/bdrc.21129
  3. Vasopressin and Alcohol: A Multifaceted Relationship doi: 10.1007/s00213-018-5099-x
  4. The Pathology of Alcohol Hangover DOI: 10.2174/1874473711003020068
  5. Alcohol Use Disorders and Current Pharmacological Therapies: The Role of GABA(A) Receptors doi: 10.1038/aps.2014.50.
  6. Alcoholic Liver Disease doi: 10.1038/s41572-018-0014-7
  7. Alcohol Use and Breast Cancer: A Critical Review doi: 10.1111/acer.13071.
  8. Light Alcohol Drinking and Cancer: A Meta-Analysis doi: 10.1093/annonc/mds337
  9. A single sip of a strong alcoholic beverage causes exposure to carcinogenic concentrations of acetaldehyde in the oral cavity. doi: 10.1016/j.fct.2011.05.024
  10. Does Diet or Alcohol Explain the French Paradox? doi: 10.1016/s0140-6736(94)92883-5.
  11. Why heart disease mortality is low in France: the time lag explanation doi: 10.1136/bmj.318.7196.1471
  12. The French paradox: lessons for other countries doi: 10.1136/heart.90.1.107

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Distributed by: A.U.M. Films & Media
Release date : March 7, 2017 (New York)
Running time: 92 minutes
Country: United States
Language: English

Know Public Health has no rights of this documentary, we just have shared the video for public health interest. All rights go to, Producers and Directors and the media house for this movie.
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Are we omnivores, carnivores or herbivores? It’s important for animals to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat? Dr. Sofia Pineda Ochoa discusses this often misunderstood topic.

The first part of the transcript is included below for reference, and the full transcript (which is too long to have here) is available on our website, along with sources and credits, at this link: http://meatyourfuture.com/2015/09/herbivores-carnivores/

[The following transcript is an approximation of the audio in  video. To hear the audio and see the accompanying visuals, please play the video.]

PARTIAL TRANSCRIPT:

Are humans herbivores, carnivores or omnivores? It’s very important for a given animal to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat?

When looking at a species to determine what they are in terms of carnivore, omnivore or herbivore, we can look at their behavior or we can look at their biology. From a behavioral standpoint, humans behave as omnivores because we observe many humans in their behavior eating a wide variety of both animal and plant-based foods. Biologically, however, from a physiologic and anatomic standpoint, it’s a different story.

Dr. Williams C. Roberts from the National Institutes of Health and Baylor University — who is the editor-in-chief of the American Journal of Cardiology and one of the most prominent cardiologists in the world with over 1,500 publications in peer reviewed medical journals — summarized our answer very nicely. He wrote:

“Although most of us conduct our lives as omnivores, in that we eat flesh as well as vegetables and fruits, human beings have characteristics of herbivores, not carnivores. The appendages of carnivores are claws; those of herbivores are hands or hooves. The teeth of carnivores are sharp; those of herbivores are mainly flat (for grinding). The intestinal tract of carnivores is short (3 times body length); that of herbivores, long (12 times body length). Body cooling of carnivores is done by panting; herbivores, by sweating. Carnivores drink fluids by lapping; herbivores, by sipping. Carnivores produce their own vitamin C, whereas herbivores obtain it from their diet. Thus, humans have characteristics of herbivores, not carnivores.”

That’s right. Humans have characteristics of herbivores, not carnivores or omnivores — because omnivores, like bears and raccoons, actually retain most of the carnivorous characteristics, so that they are still able to digest and hunt their prey, and do so effectively.

[Remainder of transcript, along with sources and credits, available here: http://meatyourfuture.com/2015/09/herbivores-carnivores]

Are we omnivores, carnivores or herbivores? It’s important for animals to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat? Dr. Sofia Pineda Ochoa discusses this often misunderstood topic.

The first part of the transcript is included below for reference, and the full transcript (which is too long to have here) is available on our website, along with sources and credits, at this link: http://meatyourfuture.com/2015/09/herbivores-carnivores/

[The following transcript is an approximation of the audio in video. To hear the audio and see the accompanying visuals, please play the video.]

PARTIAL TRANSCRIPT:

Are humans herbivores, carnivores or omnivores? It’s very important for a given animal to eat what they are physiologically and anatomically designed to eat, to improve the chances of survival and health. So, what are humans designed to eat?

When looking at a species to determine what they are in terms of carnivore, omnivore or herbivore, we can look at their behavior or we can look at their biology. From a behavioral standpoint, humans behave as omnivores because we observe many humans in their behavior eating a wide variety of both animal and plant-based foods. Biologically, however, from a physiologic and anatomic standpoint, it’s a different story.

Dr. Williams C. Roberts from the National Institutes of Health and Baylor University — who is the editor-in-chief of the American Journal of Cardiology and one of the most prominent cardiologists in the world with over 1,500 publications in peer reviewed medical journals — summarized our answer very nicely. He wrote:

“Although most of us conduct our lives as omnivores, in that we eat flesh as well as vegetables and fruits, human beings have characteristics of herbivores, not carnivores. The appendages of carnivores are claws; those of herbivores are hands or hooves. The teeth of carnivores are sharp; those of herbivores are mainly flat (for grinding). The intestinal tract of carnivores is short (3 times body length); that of herbivores, long (12 times body length). Body cooling of carnivores is done by panting; herbivores, by sweating. Carnivores drink fluids by lapping; herbivores, by sipping. Carnivores produce their own vitamin C, whereas herbivores obtain it from their diet. Thus, humans have characteristics of herbivores, not carnivores.”

That’s right. Humans have characteristics of herbivores, not carnivores or omnivores — because omnivores, like bears and raccoons, actually retain most of the carnivorous characteristics, so that they are still able to digest and hunt their prey, and do so effectively.

[Remainder of transcript, along with sources and credits, available here: http://meatyourfuture.com/2015/09/herbivores-carnivores]

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YouTube Video UExXSlpBTjg5dURrWGF0Wkl0aDlDZG55UE1ZcEZ5dUlrbC5DRUQwODMxQzUyRTlGRkY3

Are humans omnivores, carnivores or herbivores?

GoVeganWay 351K views September 4, 2021 12:32 am

How much is a human life worth? An innovative cancer therapy promises to save lives. But it is extremely expensive. Will the insurance companies pay for it? What is the manufacturer's return on investment? And do lobbyists drive up prices?

In 2018, the Kymriah gene therapy was approved in Europe. Immune cells are taken from the patient, genetically reprogrammed into cancer killer cells and returned to the patient as an infusion. The results of the Kymriah study only cover a period of 18 months. In 40 percent of patients, lymph gland cancer does not return during this time. It is not clear whether Kymriah has a long-term effect. The Swiss pharmaceutical company Novartis offers the new therapy - it costs 370,000 Swiss francs per patient. Health insurance companies are not usually prepared to pay that much and are complaining about a lack of transparency. 

But the killer cells were not invented in the Novartis laboratories, but at a US university. When Professor Carl June started his research almost 30 years ago, no pharmaceutical company was interested. It was only thanks to funding from tax money and donations that he was able to develop Kymriah at all. After a story went around the world about a girl with leukemia whose cancer disappeared thanks to Kymriah, the pharmaceutical company contacted Novartis and secured exclusive marketing rights. To launch Kymriah on the market, Novartis funded the necessary clinical trials. It's not an isolated incident: Over 60% of newly approved medicines in the US are developed by small biotech companies or universities. Pharmaceutical companies today frequently act as capital providers, cooperating with universities or buying up biotech companies. 

A paradigm shift has taken place in the pharmaceutical industry: Whereas high drug prices used to be justified by research costs, the industry is now using the value of gained lifetime to argue its case. 

 -------------------------------------------------------------------

DW Documentary gives you knowledge beyond the headlines. Watch high-class documentaries from German broadcasters and international production companies. Meet intriguing people, travel to distant lands, get a look behind the complexities of daily life and build a deeper understanding of current affairs and global events. Subscribe and explore the world around you with DW Documentary.

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How much is a human life worth? An innovative cancer therapy promises to save lives. But it is extremely expensive. Will the insurance companies pay for it? What is the manufacturer's return on investment? And do lobbyists drive up prices?

In 2018, the Kymriah gene therapy was approved in Europe. Immune cells are taken from the patient, genetically reprogrammed into cancer killer cells and returned to the patient as an infusion. The results of the Kymriah study only cover a period of 18 months. In 40 percent of patients, lymph gland cancer does not return during this time. It is not clear whether Kymriah has a long-term effect. The Swiss pharmaceutical company Novartis offers the new therapy - it costs 370,000 Swiss francs per patient. Health insurance companies are not usually prepared to pay that much and are complaining about a lack of transparency.

But the killer cells were not invented in the Novartis laboratories, but at a US university. When Professor Carl June started his research almost 30 years ago, no pharmaceutical company was interested. It was only thanks to funding from tax money and donations that he was able to develop Kymriah at all. After a story went around the world about a girl with leukemia whose cancer disappeared thanks to Kymriah, the pharmaceutical company contacted Novartis and secured exclusive marketing rights. To launch Kymriah on the market, Novartis funded the necessary clinical trials. It's not an isolated incident: Over 60% of newly approved medicines in the US are developed by small biotech companies or universities. Pharmaceutical companies today frequently act as capital providers, cooperating with universities or buying up biotech companies.

A paradigm shift has taken place in the pharmaceutical industry: Whereas high drug prices used to be justified by research costs, the industry is now using the value of gained lifetime to argue its case.

-------------------------------------------------------------------

DW Documentary gives you knowledge beyond the headlines. Watch high-class documentaries from German broadcasters and international production companies. Meet intriguing people, travel to distant lands, get a look behind the complexities of daily life and build a deeper understanding of current affairs and global events. Subscribe and explore the world around you with DW Documentary.

Subscribe to:
DW Documentary: https://www.youtube.com/channel/UCW39zufHfsuGgpLviKh297Q?sub_confirmation=1#

DW Documental (Spanish): https://www.youtube.com/dwdocumental
DW Documentary وثائقية دي دبليو: (Arabic): https://www.youtube.com/dwdocarabia

For more visit:
http://www.dw.com/en/tv/docfilm/s-3610
Instagram:
https://www.instagram.com/dwdocumentary/
Facebook:
https://www.facebook.com/dw.stories

DW netiquette policy: https://p.dw.com/p/MF1G

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YouTube Video UExXSlpBTjg5dURrWGF0Wkl0aDlDZG55UE1ZcEZ5dUlrbC41NkI0NEY2RDEwNTU3Q0M2

The power of the pharmaceutical companies | DW Documentary

GoVeganWay 648.6K views September 4, 2021 12:24 am

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