Lectins- Paradox of the “Plant Paradox”
The paradox of the “Plant Paradox” is that people who eat more lectins (beans and whole grains) have less cancer.
Milos Pokimica
Written By: Milos Pokimica
Medically Reviewed by: Dr. Xiùying Wáng, M.D.
Updated May 7, 2023The paradox of the “Plant Paradox” is that people who eat more lectins (beans and whole grains) have less cancer.
There is always some “evil” and some reason why people should avoid eating the whole plant-based food diet and usually, these types of books are well received and well-promoted by mainstream media. After reading the book “Plant Paradox” someone might get the idea that eating raw plant foods might get him sick because of the antinutrients and that the best thing is to avoid this type of toxins like lectins. Go with a high protein lean meat, right, and healthy fats like fish.
The truth is that the food is usually designed to be eaten raw by nature itself. Eating raw vegetables is better than cooked but eating raw beans, for example, can kill you dead. Five raw dried red kidney beans are enough to cause vomiting diarrhea and pain. That is because the substances called lectins, chemicals that paleo diet people find to be one of the root causes of all evil.
To some extent, they can be right. Lectins are a family of proteins that bind to carbohydrates. They are sugar-binding and convert to the glyco portion of glycoconjugates in the cell membranes. The main constituents of human cell membranes include lipids, glycoproteins, lipid-linked proteins, and proteins. So they are in all of us. Lectins are proven to play a different role in cell growth, cell death, body fat regulation, and immune functions. Some of them no one should be consuming ever. However, some of them are necessary.
Since plants cannot move, they use their natural chemistry to protect themselves from microorganisms, insects, and other animals. One of the defensive chemicals is lectins. They are not to be confused with leptin, which is a satiety peptide hormone produced almost exclusively in fat tissue. Lectins play a role in different biological systems. Not just in the human body but also in animals, plants, bacteria, and even viruses. Some are toxic, inflammatory, or both and can have anti-nutrient value. They can block the absorption of some nutrients. Some are beneficial and have anti-cancerogenic activity. There is a wide variety of them.
Most of them are destroyed by cooking, but some are resistant to cooking and digestive enzymes, but again some of them are destroyed by sprouting. In nature seeds have to stay fresh and ready to sprout so naturally in the seed there are chemicals that will kill all of the putrefying bacteria. These chemicals can be deactivated by soaking, which is the beginning of sprouting. When the seed starts to sprout it neutralizes its protective preservative chemicals that can have ant nutrient and toxic effects.
Avoiding lectins is not possible or almost impossible because they are present in all of our food. They are abundant in raw legumes and grains and in some vegetables, but the more problematic lectins are found primarily in legumes. Some in wheat can also be problematic.
Wheat gliadin, which causes coeliac disease, is a lectin-like substance and it binds to the human intestinal mucosa. Gliadin has been theorized as the coeliac disease toxin for over 20 years. Because we do not digest lectins, they passed into our blood circulation, so we often produce antibodies to them. Everyone has antibodies to some dietary lectins. The appearance of different lectins can stimulate an immune system response. However, depending on the individual, the response can vary. In some individuals, some types of foods can become intolerable after the immune system change or after the permeability of the intestinal line increase so the immune system response will have to increase as well.
If we have developed antibodies to them that can be a problem not because of the lectin itself but because of something called molecular mimicry. And that can be a real nightmare. If some chemical gets to our bloodstream and our immune system makes antibodies to that chemical and if the chemical is similar to some of our own cells, meaning it has a sequence of amino acids that are the same as the sequence in some of our own cells, then the bad things are going to happen. After cleaning the evil intruder chemical, the antibody will detect our own cell as the same chemical and will attack our own living tissue eating us from the inside. When the immune system by mistake of molecular mimicry starts to attack our own cells, the horrors of never curable autoimmune disease begin.
The great news is that lectins are not similar genetically to us because they are from the plant kingdom that has different cells than our own and will not cause autoimmune reactions. However, it still can cause allergies and inflammation. Many lectins are potent allergens. For instance, prohevein is the primary allergen of rubber latex. In recent years, a new strain of genetically modified tomatoes has been created that has added genes for the production of prohevein because of its fungistatic properties. Because of this in the future, we can expect a rise in tomato allergies among latex-sensitive individuals.
Of specific interest is the fact that lectins can stimulate class II HL antigens on cells that do not usually display them, such as pancreatic islet and thyroid cells. Insulin-dependent diabetes, therefore, can be a potential lectin disease. Another possible correlation to a lectin disease is rheumatoid arthritis. In diet-responsive rheumatoid arthritis, one of the most typical trigger foods is wheat. Some of the effects observed in the small intestine in rodents were stripping away of the mucous coat and exposing naked mucosa to abnormal bacteria growth. Lectins also stimulate acid secretion by causing a release of histamine from gastric mast cells. Three central pathogenic constituents for peptic ulcer, stripping away of the mucous defense layer, abnormal bacterial proliferation (Helicobacter pylori), then release of histamine and acid stimulation are all theoretically linked to lectins.
However, if we all eat lectins, why don’t we all get peptic ulcers, rheumatoid arthritis, and insulin-dependent diabetes? Partially because cells are preserved behind a fine screen of sialic acid molecules and partially because of natural changes in the glycoconjugates that coat our cells. However, the sialic acid molecules can be stripped off by the enzyme called neuraminidase, present in several micro-organisms such as streptococci and influenza viruses. This may reveal why diabetes and rheumatoid arthritis tend to occur as a sequence of infections. The best thing to do when you are sick is to listen to your body not your mom and not eat.
What can happen that is potentially dangerous is the situation when lectins affect the gut wall, and we eat food from the animal kingdom that is genetically similar to our own cells. Lectins can cause inflammation and create damage to the lining of the intestines. If this damage is not regenerated fast enough, the gut can become leaky allowing various molecules (including stuff we do not want) to pass into the bloodstream and that is one of the main factors that are responsible for the creation of autoimmune diseases.
In normal situations for most people, lectin inflammation usually is not at the level that is dangerous and should not be the problem but if you have an allergy to some of the lectins, then it might. The brain is the brain, and muscle is a muscle, sort of speak, so if at the same time we have leaky gut and eat animal tissue, autoimmune diseases are theoretically possible, especially because of our low level of stomach acidity that cannot dissolve animal protein completely. Globular undigested proteins from animal tissue similar to our own tissue entering our bloodstream because of the lectin inflammation in the gut are a recipe for autoimmune diseases. The only thing that is normal is individual amino acids passing thru, if we have more amino acids in the chain in the blood then it is a potential invader swimming around and the immune system steps into action.
For people with leaky gut, Crohn’s disease, and any type of problem with digestion eating animal protein is in my opinion one leg in the grave. A true carnivore with stomach acidity of pH one does not have to worry about this. Also when enough lectins are consumed, it can signal our body to evacuate GI contents. This means vomiting, cramping, and diarrhea. It may further induce a comprehensive immune system response creating inflammation as the body’s defenses move in to attack the invaders.
If you eat animal protein or even if you do not, it is a good idea to do allergic testing for every type of food early in childhood because food allergies can cascade into the leaky gut, then into autoimmune diseases like diabetes type 1 or multiple sclerosis.
The worst and the most famous lectin is ricin produced in the seeds of the castor oil plant, Ricinus communis. Ricin was even used in an experimental military chemical warfare program during World War 1. There was an attempt to make coating bullets and ricin bombs, but the program did not prove to be particularly useful. It takes precisely 1.78mg of ricin to kill an average adult person. It can even be inhaled. That is about the same amount as a few grains of table salt which ricin resembles visually. It is untraceable in toxicology examinations because the poison is just a catalyst that will start a chain reaction in the body. When the first symptoms begin to show the ricin is already destroyed and cannot be detected in the body. It is at least ten times more toxic than the most potent nerve gas. A 1% water solution with an explosive burster has the same effectiveness as sarin nerve gas. That is the power of the plants. The only disadvantage ricin has is the time it needs for the victims to die. It will not have the quick tactical effect of nerve gas like sarin if you use it in combat, so it was abandoned as a military weapon. However, for single covert assassinations, it is a useful substance because the assassin can escape long before the first symptoms of poisoning have been detected. Bulgarian dissident Georgi Markov was killed in this way back in 1978 in the middle of the street in London by stabbing him from behind with an umbrella. The weaponized umbrella had ricin, and when he was stabbed in the leg with it, it was game over. He died four days later. There is no antidote currently available for ricin poisoning, only some experimental stuff that is not available to the public and not very reliable because the antidote only works while ricin is still in the blood. Usually when the first symptoms start it is already too late. If exposed death is guaranteed. Only vaccination is possible and only effective for several months by injecting an inactive form of the protein chain.
The Breaking Bad series actually inspired several real-life criminal cases involving ricin poisoning. The US government has done everything it can to hide copies of this deadly poison, but in reality, I was able to find one in a couple of minutes. Castor oil seeds contain around 5-10 percent ricin. You just have to remove the oil and fiber and filter it out. Even five to ten raw ground castor seeds will kill an adult human without making the poison. And yes castor oil is perfectly safe, according to the FDA and your grandma, ricin is not in castor oil. When we know about stuff like this, it is easy to spread hysteria about lectins like the book Plant Paradox and other bad science made to sell lectin shield products and diets. Also, lectins in the diet are not blood-type specific, so the blood type diet is just wrong. It reminds me of the gluten story. Lectin avoidance can become a new gluten scam. While many types of lectins are dangerous, there are also health-promoting lectins that can decrease the incidence of certain diseases.
Furthermore, they are necessary for some of the essential biochemical processes in which the body uses lectins to achieve many essential functions, including programmed cell death, inflammatory modulation, and cell to cell adherence. The ones that can cause problems are the ones in beans and if you have food allergies and that is it. Actually low doses of lectins are beneficial by ameliorating obesity, limiting tumor growth, and stimulating gut function. Especially for colon cancer. Ricin itself has been under several experiments as a new drug for cancer treatment. There are lectins that kill cancer cells and at the same time don’t do anything to normal cells. There are even lectins that force mutagenic cancer cells to go back into regular ones without killing them. The interest started back in 1963 after the discovery that lectins can distinguish between normal and malignant cells. Lectins are so specific that a stool sample can predict the presence of polyps and cancers on the basis of lectin binding to the colon lining cells. In a Petri dish, they have so far been able to kill a wide variety of cancers.
Because most of the lectins are in the intestines the benefits for colorectal cancer are the highest because most of them will come into contact with colon cells before they are absorbed. Big pharma currently researches different lectins, and it is expected that in the future there will be lectin-based drugs. When we look at studies, dietary consumption of beans has been correlated to a lower risk of colorectal cancer, diabetes risk, and mortality from all cases. Consumption of whole grains had been correlated with reduced risk of heart disease, strokes, diabetes, cancer, and mortality from all causes. The same story with other high lectin whole foods. If you are not allergic eating tomatoes or whole grains or beans will actually reduce the overall inflammation in the body even with all of the inflammatory lectins in them. Only legumes are poisonous when raw.

So how do we remove the lectins from the beans?
If beans are soaked for 5 hours, then 15 minutes of cooking will completely eliminate all lectins in them. If you use a pressure cooker, then the time is under 8 minutes. Before the beans are palatable, the lectins would be long gone. If beans are not soaked, then around 45 minutes of pressure cooking will eliminate them but still, they will be palatable after 60 minutes. At any rate, the beans would be free from all lectins if palatable no matter what way we cooked them. One important note, lectins are to some degree resistant to dry heat such as what would occur in baking. Cooking with legume flower that is not soaked and cooked first is not a traditional way but also not prudent or smart. The second line of defense against lectins is plain carbohydrates because lectins bind to them instantly. The minor quantities of lectins left after soaking and cooking bind with free carbs in the foods and are effectively deactivated. Only individuals eating a raw diet with certain acute or chronic infections like leaky gut or other conditions may find that lectin minimization is necessary but even in their case it might not be. Lectins are here to stay, but there are some other types of natural toxins besides lectins that we should try to minimize.
References:
Passages selected from a book: Pokimica, Milos. Go Vegan? Review of Science Part 1. Kindle ed., Amazon, 2018.
- Aune, Dagfinn et al. “Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies.” BMJ (Clinical research ed.) vol. 353 i2716. 14 Jun. 2016, doi:10.1136/bmj.i2716
- Aune, Dagfinn et al. “Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies.” BMJ (Clinical research ed.) vol. 353 i2716. 14 Jun. 2016, doi:10.1136/bmj.i2716
- Van Buul, Vincent J., and Fred Brouns. “Health Effects of Wheat Lectins: A Review.” Journal of Cereal Science, vol. 59, no. 2, Elsevier BV, Mar. 2014, pp. 112–17. https://doi.org/10.1016/j.jcs.2014.01.010.
- Chan, Yau Sang et al. “White kidney bean lectin exerts anti-proliferative and apoptotic effects on cancer cells.” International journal of biological macromolecules vol. 85 (2016): 335-45. doi:10.1016/j.ijbiomac.2015.12.094
- De Mejía, Elvira González, and Valentin I Prisecaru. “Lectins as bioactive plant proteins: a potential in cancer treatment.” Critical reviews in food science and nutrition vol. 45,6 (2005): 425-45. doi:10.1080/10408390591034445
- Hamid, Rabia, and Akbar Masood. “Dietary Lectins as Disease Causing Toxicants.” Pakistan Journal of Nutrition, vol. 8, no. 3, Asian Network for Scientific Information, Mar. 2009, pp. 293–303. https://doi.org/10.3923/pjn.2009.293.303.
Related Posts
Do you have any questions about nutrition and health?
I would love to hear from you and answer them in my next post. I appreciate your input and opinion and I look forward to hearing from you soon. I also invite you to follow us on Facebook, Instagram, and Pinterest for more diet, nutrition, and health content. You can leave a comment there and connect with other health enthusiasts, share your tips and experiences, and get support and encouragement from our team and community.
I hope that this post was informative and enjoyable for you and that you are prepared to apply the insights you learned. If you found this post helpful, please share it with your friends and family who might also benefit from it. You never know who might need some guidance and support on their health journey.
– You Might Also Like –

Learn About Nutrition
Milos Pokimica is a doctor of natural medicine, clinical nutritionist, medical health and nutrition writer, and nutritional science advisor. Author of the book series Go Vegan? Review of Science, he also operates the natural health website GoVeganWay.com
Medical Disclaimer
GoVeganWay.com brings you reviews of the latest nutrition and health-related research. The information provided represents the personal opinion of the author and is not intended nor implied to be a substitute for professional medical advice, diagnosis, or treatment. The information provided is for informational purposes only and is not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider.NEVER DISREGARD PROFESSIONAL MEDICAL ADVICE OR DELAY SEEKING MEDICAL TREATMENT BECAUSE OF SOMETHING YOU HAVE READ ON OR ACCESSED THROUGH GoVeganWay.com
NEVER APPLY ANY LIFESTYLE CHANGES OR ANY CHANGES AT ALL AS A CONSEQUENCE OF SOMETHING YOU HAVE READ IN GoVeganWay.com BEFORE CONSULTING LICENCED MEDICAL PRACTITIONER.
In the event of a medical emergency, call a doctor or 911 immediately. GoVeganWay.com does not recommend or endorse any specific groups, organizations, tests, physicians, products, procedures, opinions, or other information that may be mentioned inside.
Editor Picks –
Milos Pokimica is a doctor of natural medicine, clinical nutritionist, medical health and nutrition writer, and nutritional science advisor. Author of the book series Go Vegan? Review of Science, he also operates the natural health website GoVeganWay.com
Latest Articles –
Plant Based News
-
M&S Launches 1-Ingredient Corn Flakes
on March 16, 2025
-
‘The One Dish I’d Cook To Win Over A Tofu Skeptic’
on March 15, 2025
-
This Naked Niçoise Salad Is Completely Vegan
on March 14, 2025
-
Juicy Marbles Unveils ‘Market First’ Plant-Based Pork Whole Cut
on March 14, 2025
-
American Red Cross Working To Provide Plant-Based Options In Shelters
on March 14, 2025
-
‘This Is The Best Sandwich I Have Ever Eaten – And It’s Vegan’
on March 14, 2025
-
UK Launches Pioneering Research Programme For Cell-Cultivated Products
on March 13, 2025
Top Health News — ScienceDaily
- Older adults might be more resistant to bird flu infections than childrenon March 13, 2025
Older adults who were exposed to seasonal flu viruses that circulated prior to 1968 are more likely to have some protection against H5N1, and children would benefit more from H5N1 vaccines.
- Lowering bioenergetic age may help fend off Alzheimer’son March 13, 2025
A person’s ‘bioenergetic age’ — or how youthfully their cells generate energy — might be a key indicator of whether they’re at risk of developing Alzheimer’s disease, new research shows. The study suggests healthy living can turn back the bioenergetic clock for some people, helping them fend off Alzheimer’s as effectively as a new drug called lecanemab.
- Portable, blood-based device detects colon canceron March 13, 2025
Scientists are developing a less invasive portable device that would use blood samples to detect colorectal cancers.
- Researchers develop method to identify dormant cells that carry HIVon March 13, 2025
Study findings provide a new gene pathway for potential treatment of the virus affecting millions.
- Chocolate — with potential health benefitson March 13, 2025
Many people will soon load up Easter baskets with chocolate candy for children and adults to enjoy. On its own, dark chocolate has health benefits, such as antioxidants that neutralize damaging free radicals. And a new report suggests that packing the sweet treat with pre- and probiotics could make it more healthful. Flavoring agents, however, can affect many properties, including moisture level and protein content of the chocolate product.
- Newly uncovered mechanism could drive next-gen cystic fibrosis treatmentson March 13, 2025
Protein clustering mechanism on the cell membrane presents a new therapeutic target for cystic fibrosis.
- When it comes to ACL injury, a dollar of prevention is worth more than seven dollars of cureon March 13, 2025
An analysis of high school soccer players suggests that incorporating a lower extremity injury prevention program results in fewer anterior cruciate ligament tears and a big reduction in health care expenses.
PubMed, #vegan-diet –
- Healthful vs. Unhealthful Plant-Based Restaurant Mealson March 13, 2025
Background: Vegan/vegetarian (VEG) restaurants and VEG options in omnivore (OMNI) restaurants may serve unhealthful plant-based food that may be more harmful than a typical American diet. Methods: A sample of 561 restaurants with online menus were analyzed over a 3-year period. Each plant-based menu entrée was counted, up to a maximum of ten entrées per restaurant, meaning that a restaurant customer could select from ten or more healthful plant-based choices. Entrées containing refined […]
- Analyzing dietary exposure to critical nutrients on a plant-based diet using the food- and total nutrient indexon March 13, 2025
CONCLUSIONS: Supplementation has a profound impact on nutrient supplies in individuals on a plant-based diet. This study reiterates the need to quantitatively assess nutrient intakes from supplements to assess diet quality of plant-based dietary patterns. We posit that defining diet-specific TNI scores is important for a precise evaluation of diet quality, whether in omnivore or in the spectrum of plant-based diets.
- Impact of Vegan and Vegetarian Diets on Neurological Health: A Critical Reviewon March 13, 2025
CONCLUSIONS: While plant-based diets provide anti-inflammatory and antioxidant benefits, their neurological implications depend on nutrient adequacy. Proper planning, supplementation, and food preparation techniques are essential to mitigate risks and enhance cognitive health. Further research is needed to explore long-term neurological outcomes and optimize dietary strategies.
- Vegan diet, processed foods, and body weight: a secondary analysis of a randomized clinical trialon March 12, 2025
Low-fat plant-based diets cause weight loss in clinical trials. However, many foods are highly processed, raising the question as to their effect on body weight. This secondary analysis assessed the associations between changes in processed food intake and weight loss in 244 overweight adults randomly assigned to a vegan (n = 122) or control group (n = 122) for 16 weeks. Three-day dietary records were analyzed using the NOVA system, which categorizes foods from 1 to 4, based on degree of…
- Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Reviewon March 12, 2025
PURPOSE OF REVIEW: Veganism, characterized by the exclusion of all animal-derived products, has grown in popularity due to ethical, environmental, and health considerations. However, vegan athletes often face unique nutritional challenges related to dietary deficiencies of critical nutrients such as proteins, vitamin B12, iron, calcium, and omega-3 fatty acids, among others. This narrative review aims to explore the efficacy and benefits of vegan-friendly supplements specifically tailored to…
Random Posts –
Featured Posts –

Latest from PubMed, #plant-based diet –
- Diabetes, obesity, and cardiovascular disease-what is the impact of lifestyle modification?by Celina Seth on March 14, 2025
Diabetes, obesity, and cardiovascular disease (CVD) represent an escalating global health challenge, contributing significantly to morbidity, mortality, and healthcare costs. Evidence from large cohort studies and clinical trials underscores the impact of diabetes and obesity as major risk factors for CVD, causing systemic inflammation, insulin resistance, and neurohormonal activation. Frequently, a sedentary lifestyle and unbalanced dietary habits are associated with these risk factors….
- Ellagic acid ameliorates atherosclerosis by inhibiting PCSK9 through the modulation of FoxO3 and HNF1αby Li-Tian Wang on March 14, 2025
CONCLUSIONS: In summary, this study demonstrates that ellagic acid inhibits PCSK9 by regulating HNF1α and FoxO3, thereby increasing LDLR levels and alleviating atherosclerosis. This finding not only consolidates the scientific basis of plant-based diets for preventing cardiovascular diseases but also provides an important direction for developing functional foods and nutritional intervention strategies based on natural polyphenols.
- Mediterranean diet: Why a new pyramid? An updated representation of the traditional Mediterranean diet by the Italian Society of Human Nutrition (SINU)by Francesco Sofi on March 14, 2025
In recent decades, an increasing body of research has highlighted significant scientific evidence linking adherence to the Mediterranean diet with a reduced risk of chronic diseases. Simultaneously, concerns about the environmental impact of the food system have intensified, particularly considering projected population growth in the coming years. This work introduces a new graphical representation of the traditional Mediterranean dietary model, developed by a dedicated Working Group of the…
- Association Between Mediterranean Diet and Other Healthy Habits and Sociodemographic Variables with the Values of Vascular and Heart Age in Spanish Workersby Natalia Montero Muñoz on March 13, 2025
Introduction: The assessment of cardiovascular risk has traditionally relied on validated scales designed to estimate the likelihood of experiencing a cardiovascular event within a specific timeframe. In recent years, novel methodologies have emerged, offering a more objective evaluation of this risk through indicators such as vascular age (VA) and heart age (HA). Objective: This study aimed to investigate the relationship between sociodemographic factors, lifestyle behaviors, and their […]
- Low Mediterranean Diet Adherence Is Associated with Poor Socioeconomic Status and Quality of Life: A Cross-Sectional Analysisby Carolina Duarte on March 13, 2025
BACKGROUND: Health-related quality of life (HRQoL) can be impacted by various environmental factors: lifestyle habits, food insecurity, social-economic status, and dietary patterns. The Mediterranean diet (MedDiet) has been associated with a healthier lifestyle and better health outcomes. The aim of this study was to determine whether greater adherence to the MedDiet was associated with better HRQoL in communities with low social and economic statuses living in two social neighborhoods, […]
- Dietary Behavioural Preferences of Spanish and German Adults and Their Translation to the Dietary Recommendations of a Personalised Nutrition App in the Framework of the Stance4Health Projectby Daniel Hinojosa-Nogueira on March 13, 2025
Background/Objectives: The influence of individual differences in the selection of food portions can have a deep effect on recommendations for personalised nutrition. In addition to typical aspects such us energy density and nutrient composition, portion size is important for dietary recommendations. This study examined the dietary behaviours and portion size selection of 224 subjects in Spain and Germany to use such information to improve dietary adherence to a personalised nutrition app….