マクガバン報告書 - 特別な関心と科学の抑圧

Alzheimer’s has long been considered irreversible, but new research challenges that assumption. Scientists discovered that severe drops in the brain’s energy supply help drive the disease—and restoring that balance can reverse damage, even in advanced cases. In mouse models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers. The results offer fresh hope that recovery may be possible.

The familiar fight between “mind as software” and “mind as biology” may be a false choice. This work proposes biological computationalism: the idea that brains compute, but not in the abstract, symbol-shuffling way we usually imagine. Instead, computation is inseparable from the brain’s physical structure, energy constraints, and continuous dynamics. That reframes consciousness as something that emerges from a special kind of computing matter, not from running the right program.

A four–amino acid peptide called CAQK has shown powerful brain-protective effects in animal models of traumatic brain injury. Delivered through a standard IV, it zeroes in on injured brain tissue, calming inflammation and reducing cell death while improving recovery. The peptide worked in both mice and pigs, whose brains are closer to humans in structure. Researchers are now preparing to move toward early human clinical trials.

Researchers have created tiny metal-based particles that push cancer cells over the edge while leaving healthy cells mostly unharmed. The particles work by increasing internal stress in cancer cells until they trigger their own shutdown process. In lab tests, they killed cancer cells far more effectively than healthy ones. The technology is still early-stage, but it opens the door to more precise and gentler cancer treatments.

Scientists studying thousands of rats discovered that gut bacteria are shaped by both personal genetics and the genetics of social partners. Some genes promote certain microbes that can spread between individuals living together. When researchers accounted for this social sharing, genetic influence on the microbiome turned out to be much stronger than previously thought. The study suggests genes can affect others indirectly, without DNA ever being exchanged.

Scientists at MIT and Stanford have unveiled a promising new way to help the immune system recognize and attack cancer cells more effectively. Their strategy targets a hidden “off switch” that tumors use to stay invisible to immune defenses—special sugar molecules on the cancer cell surface that suppress immune activity. Early tests show it can supercharge immune responses and outperform current antibody therapies.

A deadly hospital fungus that resists nearly every antifungal drug may have an unexpected weakness. Researchers discovered that Candida auris activates specific genes during infection to hunt for nutrients it needs to survive. This insight came from a new living-host model that allowed scientists to watch the fungus in action. The findings could eventually lead to new treatments or allow current drugs to be repurposed.